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A small-molecule probe induces a conformation in HIV TAR RNA capable of binding drug-like fragments.
J Mol Biol. 2011 Jul 29;410(5):984-96. doi: 10.1016/j.jmb.2011.03.039.
2
Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic "hot spots".
J Mol Biol. 2004 Feb 13;336(2):343-56. doi: 10.1016/j.jmb.2003.12.046.
4
A Cyclic Mimic of HIV Tat Differentiates Similar TAR RNAs on the Basis of Distinct Dynamic Behaviors.
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Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein.
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6
Discoveries of Tat-TAR interaction inhibitors for HIV-1.
Curr Drug Targets Infect Disord. 2005 Dec;5(4):433-44. doi: 10.2174/156800505774912901.
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Identification of biologically active, HIV TAR RNA-binding small molecules using small molecule microarrays.
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Fragment based search for small molecule inhibitors of HIV-1 Tat-TAR.
Bioorg Med Chem Lett. 2014 Dec 15;24(24):5576-5580. doi: 10.1016/j.bmcl.2014.11.004. Epub 2014 Nov 6.

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Targeting the SARS-CoV-2 RNA Translation Initiation Element SL1 by Molecules of Low Molecular Weight.
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Identifying small-molecules binding sites in RNA conformational ensembles with SHAMAN.
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Minimization of the E. coli ribosome, aided and optimized by community science.
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Structural and computational studies of HIV-1 RNA.
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Fragment-Based Approaches to Identify RNA Binders.
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Implications of Fragment-Based Drug Discovery in Tuberculosis and HIV.
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Forging a Functional Cure for HIV: Transcription Regulators and Inhibitors.
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SILCS-RNA: Toward a Structure-Based Drug Design Approach for Targeting RNAs with Small Molecules.
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fingeRNAt-A novel tool for high-throughput analysis of nucleic acid-ligand interactions.
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Characterization of Ligand Binding by Saturation Transfer Difference NMR Spectroscopy.
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Essential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat protein.
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Fragment-based discovery of novel thymidylate synthase leads by NMR screening and group epitope mapping.
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Domain-elongation NMR spectroscopy yields new insights into RNA dynamics and adaptive recognition.
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electronic Ligand Builder and Optimization Workbench (eLBOW): a tool for ligand coordinate and restraint generation.
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Conformational inhibition of the hepatitis C virus internal ribosome entry site RNA.
Nat Chem Biol. 2009 Nov;5(11):823-5. doi: 10.1038/nchembio.217. Epub 2009 Sep 20.
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Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein.
Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):11931-6. doi: 10.1073/pnas.0900629106. Epub 2009 Jul 7.
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Design and implementation of an ribonucleic acid (RNA) directed fragment library.
J Med Chem. 2009 Jun 25;52(12):3753-61. doi: 10.1021/jm9000659.
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Structures of HIV TAR RNA-ligand complexes reveal higher binding stoichiometries.
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Recent developments in fragment-based drug discovery.
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