Beck C, Berberich W, Bauknecht A, Schnabel K
Abteilung für Strablentherapie, Radiologische Universitätsklinik, Hamburg/Saar.
Strahlenther Onkol. 1990 Dec;166(12):798-802.
Between 1983 and 1988 90 patients with bronchial neoplasms needed emergency irradiation to treat superior vena cava syndrome. Pathohistologically verified were 30 cases with squamous cell carcinoma, twelve with adenocarcinoma, five cases with large cell carcinoma, 30 with a small cell carcinoma, and non-differentiated in five others. No histological examination was carried out in eight cases. Im 30 patients distant metastases were evident at the initial diagnosis. The average duration of follow-up was 118 days. The survival course proved to be independent of histopathological grading, previous treatment, and age. Similarly no influence of the fractionation employed could be seen. Very important to the prognosis however, were the stage of disease, the Karnofsky index, and dependent on that, the total reference dose applied. Patients with a Karnofsky index of 50% or lower survived on average only 17 days.
1983年至1988年间,90例支气管肿瘤患者因上腔静脉综合征需要进行紧急放疗。经病理组织学证实,其中30例为鳞状细胞癌,12例为腺癌,5例为大细胞癌,30例为小细胞癌,另有5例为未分化癌。8例未进行组织学检查。30例患者在初诊时即有远处转移。平均随访时间为118天。生存过程证明与组织病理学分级、既往治疗及年龄无关。同样,所采用的分割方式也未见影响。然而,对预后非常重要的是疾病分期、卡氏指数,以及在此基础上所应用的总参考剂量。卡氏指数为50%或更低的患者平均仅存活17天。