Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.
J Hosp Infect. 2011 Sep;79(1):27-31. doi: 10.1016/j.jhin.2011.05.018. Epub 2011 Jul 20.
Norovirus has been associated with excess deaths. A retrospective study of mortality following norovirus enteritis (NVE) was undertaken. All hospitalized adult patients with a stool sample positive for norovirus genogroup II on polymerase chain reaction, treated at Sahlgrenska University Hospital, Gothenburg, Sweden between August 2008 and June 2009, were included as cases (N = 598, aged 18-101 years). Matched controls without enteritis (N = 1196) were selected for comparison. Medical records were reviewed and deaths up to 90 days following positive sampling were noted, as well as comorbidities and length of hospital stay. Thirty- and 90-day survival rates were calculated. Total 30-day mortality was 7.6% and no deaths were recorded in cases aged 18-59 years. Thirty-day mortality was higher in cases with underlying medical conditions compared with those without these comorbidities (age 60-101 years: 89.5% vs 94.7% alive at Day 30, respectively; P < 0.05). In cases aged > 80 years, mortality was higher in those with community-onset NVE (N = 64) compared with hospital-onset NVE (N = 305) (81.2% vs 90.2% alive at Day 30, respectively; P < 0.05), and compared with controls (N = 128) (81.2% vs 91.4% alive at Day 30, respectively; P < 0.05). Median length of hospital stay was 20 [interquartile range (IQR) 12-29] days for cases with hospital-onset NVE, and seven (IQR 2-13) days for controls (P < 0.001). In conclusion, community-onset NVE requiring hospitalization was associated with higher mortality compared with hospital-onset NVE and matched controls in hospitalized elderly patients.
诺如病毒与超额死亡有关。我们开展了一项关于诺如病毒肠炎（NVE）后死亡率的回顾性研究。所有在瑞典哥德堡萨赫格伦斯卡大学医院住院、粪便样本经聚合酶链反应检测到诺如病毒基因 II 群阳性的成年患者（2008 年 8 月至 2009 年 6 月）均被纳入病例组（598 例，年龄 18-101 岁）。为了进行比较，我们选择了没有肠炎的匹配对照（1196 例）。我们对病历进行了回顾，并记录了阳性样本后 90 天内的死亡情况，以及合并症和住院时间。我们计算了 30 天和 90 天的生存率。总 30 天死亡率为 7.6%，年龄在 18-59 岁的患者中没有死亡记录。与无合并症的患者相比，有基础疾病的患者在 30 天内的死亡率更高（年龄 60-101 岁：分别为 89.5%和 94.7%在第 30 天存活；P<0.05）。在年龄 > 80 岁的患者中，社区获得性 NVE（64 例）患者的死亡率高于医院获得性 NVE（305 例）（分别为 81.2%和 90.2%在第 30 天存活；P<0.05），也高于对照组（128 例）（分别为 81.2%和 91.4%在第 30 天存活；P<0.05）。医院获得性 NVE 病例的中位住院时间为 20 天（四分位距 [IQR] 12-29），对照组为 7 天（IQR 2-13；P<0.001）。总之，与医院获得性 NVE 和住院老年患者的匹配对照组相比，需要住院的社区获得性 NVE 与更高的死亡率相关。
