Department of Gastrointestinal, Emerging and Zoonotic Infections, Health Protection Agency Centre for Infections, UK.
Epidemiol Infect. 2010 Oct;138(10):1454-8. doi: 10.1017/S0950268810000439. Epub 2010 Mar 3.
Norovirus is a major cause of infectious intestinal disease, and a substantial prevalence of asymptomatic infection has been reported. We describe the prevalence, seasonality and characteristics of asymptomatic norovirus infection in England. Healthy individuals were recruited at random from the general population during the Study of Infectious Intestinal Disease (1993-1996). Norovirus was identified using real-time RT-PCR. The age-adjusted prevalence of asymptomatic norovirus infection was 12%; prevalence was highest in children aged <5 years and showed wintertime seasonality. More work is needed to understand whether asymptomatic infections are important for norovirus transmission leading to sporadic illness and outbreaks.
诺如病毒是传染性肠道疾病的主要病因，有大量无症状感染的报告。我们描述了英国诺如病毒无症状感染的流行率、季节性和特征。在传染性肠道疾病研究期间（1993-1996 年），我们随机从普通人群中招募健康个体。使用实时 RT-PCR 鉴定诺如病毒。无症状诺如病毒感染的年龄调整流行率为 12%；流行率在<5 岁的儿童中最高，并呈现冬季季节性。需要进一步研究来了解无症状感染是否对导致散发性疾病和暴发的诺如病毒传播很重要。
