膜运输分拣中心：跨高尔基网络中 PI4P 和小 GTP 酶之间的合作。
Membrane-trafficking sorting hubs: cooperation between PI4P and small GTPases at the trans-Golgi network.
机构信息
Department of Molecular Biology and Genetics, 107 Biotechnology Bldg., Cornell University, Ithaca, NY 14853-7202, USA.
出版信息
Trends Cell Biol. 2011 Sep;21(9):515-25. doi: 10.1016/j.tcb.2011.05.005. Epub 2011 Jul 19.
Abstract
Cell polarity in eukaryotes requires constant sorting, packaging and transport of membrane-bound cargo within the cell. These processes occur in two sorting hubs: the recycling endosome for incoming material and the trans-Golgi network for outgoing material. Phosphatidylinositol 3-phosphate and phosphatidylinositol 4-phosphate are enriched at the endocytic and exocytic sorting hubs, respectively, where they act together with small GTPases to recruit factors to segregate cargo and regulate carrier formation and transport. In this review, we summarize the current understanding of how these lipids and GTPases regulate membrane trafficking directly, emphasizing the recent discoveries of phosphatidylinositol 4-phosphate functions at the trans-Golgi network.
摘要
真核生物的细胞极性需要不断地对细胞内的膜结合货物进行分类、包装和运输。这些过程发生在两个分拣中心：回收内体用于接收物质，以及高尔基网络用于输出物质。磷脂酰肌醇 3-磷酸和磷脂酰肌醇 4-磷酸分别在内吞和外排分拣中心富集，在那里它们与小 GTP 酶一起作用，招募因子来分隔货物并调节载体的形成和运输。在这篇综述中，我们总结了目前对这些脂质和 GTP 酶如何直接调节膜运输的理解，强调了最近在高尔基网络中发现的磷脂酰肌醇 4-磷酸的功能。
相似文献
1
Membrane-trafficking sorting hubs: cooperation between PI4P and small GTPases at the trans-Golgi network.膜运输分拣中心：跨高尔基网络中 PI4P 和小 GTP 酶之间的合作。
Trends Cell Biol. 2011 Sep;21(9):515-25. doi: 10.1016/j.tcb.2011.05.005. Epub 2011 Jul 19.
2
Unveiling the cryo-EM structure of retromer.揭示返回蛋白的冷冻电镜结构。
Biochem Soc Trans. 2020 Oct 30;48(5):2261-2272. doi: 10.1042/BST20200552.
3
pH Biosensing by PI4P Regulates Cargo Sorting at the TGN.PI4P 通过 pH 生物传感调节 TGN 中的货物分拣。
Dev Cell. 2020 Feb 24;52(4):461-476.e4. doi: 10.1016/j.devcel.2019.12.010. Epub 2020 Jan 9.
4
Plant endosomes as protein sorting hubs.植物内体作为蛋白质分拣中心。
FEBS Lett. 2022 Sep;596(17):2288-2304. doi: 10.1002/1873-3468.14425. Epub 2022 Jun 17.
5
SIMPLE binds specifically to PI4P through SIMPLE-like domain and participates in protein trafficking in the trans-Golgi network and/or recycling endosomes.SIMPLE 通过 SIMPLE 样结构域特异性地结合 PI4P，并参与跨高尔基网络和/或再循环内体中的蛋白质运输。
PLoS One. 2018 Jun 28;13(6):e0199829. doi: 10.1371/journal.pone.0199829. eCollection 2018.
6
Phosphoinositides and membrane traffic at the trans-Golgi network.磷酸肌醇与反式高尔基体网络处的膜运输
Biochem Soc Symp. 2005(72):31-8. doi: 10.1042/bss0720031.
7
From endosomes to the trans-Golgi network.从内体到反式高尔基体网络。
Semin Cell Dev Biol. 2014 Jul;31:30-9. doi: 10.1016/j.semcdb.2014.04.024. Epub 2014 Apr 23.
8
Dual control of membrane targeting by PtdIns(4)P and ARF.磷脂酰肌醇-4-磷酸（PtdIns(4)P）和ADP核糖基化因子（ARF）对膜靶向的双重调控
Trends Biochem Sci. 2004 Oct;29(10):513-5. doi: 10.1016/j.tibs.2004.08.007.
9
A TOCA/CDC-42/PAR/WAVE functional module required for retrograde endocytic recycling.逆行内吞循环所需的一种TOCA/CDC-42/PAR/WAVE功能模块。
Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1443-52. doi: 10.1073/pnas.1418651112. Epub 2015 Mar 9.
10
Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b.Golgi 相关逆行蛋白 (GARP) 复合物依赖性内体到反式高尔基体网络逆行运输由 Rab4b 控制。
Cell Mol Biol Lett. 2024 Apr 16;29(1):54. doi: 10.1186/s11658-024-00574-w.
引用本文的文献
1
Cargo adaptors use a handhold mechanism to engage with myosin V for organelle transport.货物衔接蛋白利用一种抓手机制与肌球蛋白V结合以进行细胞器运输。
J Cell Biol. 2025 Jul 7;224(7). doi: 10.1083/jcb.202408006. Epub 2025 May 16.
2
Dysregulation of PI4P in the trans Golgi regions activates the mammalian Golgi stress response.反式高尔基体区域中磷脂酰肌醇-4-磷酸（PI4P）的失调会激活哺乳动物的高尔基体应激反应。
J Biol Chem. 2025 Jan;301(1):108075. doi: 10.1016/j.jbc.2024.108075. Epub 2024 Dec 13.
3
A type II phosphatidylinositol-4-kinase coordinates sorting of cargo polarizing by endocytic recycling.一种 II 型磷脂酰肌醇-4-激酶协调通过内吞回收来进行货物极化的分拣。
Commun Biol. 2024 Jul 12;7(1):855. doi: 10.1038/s42003-024-06553-3.
4
Sac1 links phosphoinositide turnover to cryptococcal virulence.Sac1 将磷酸肌醇周转率与隐球菌毒力联系起来。
mBio. 2024 Aug 14;15(8):e0149624. doi: 10.1128/mbio.01496-24. Epub 2024 Jul 2.
5
Recruitment of PI4KIIIβ to the Golgi by ACBD3 is dependent on an upstream pathway of a SNARE complex and golgins.通过 ACBD3 将 PI4KIIIβ 招募到高尔基体取决于 SNARE 复合物和高尔基体的上游途径。
Mol Biol Cell. 2024 Feb 1;35(2):ar20. doi: 10.1091/mbc.E23-09-0376. Epub 2023 Dec 22.
6
The intracellular and plasma membrane pools of phosphatidylinositol-4-monophosphate control megakaryocyte maturation and proplatelet formation.磷脂酰肌醇-4-单磷酸的细胞内池和质膜池控制巨核细胞成熟和前血小板形成。
Res Pract Thromb Haemost. 2023 Apr 26;7(4):100169. doi: 10.1016/j.rpth.2023.100169. eCollection 2023 May.
7
A sterol-PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response.甾醇-PI(4)P 交换器调节 DNA 损伤反应的 Tel1/ATM 轴。
EMBO J. 2023 Aug 1;42(15):e112684. doi: 10.15252/embj.2022112684. Epub 2023 Jun 12.
8
PI4P-Containing Vesicles from Golgi Contribute to Mitochondrial Division by Coordinating with Polymerized Actin.富含 PI4P 的小泡通过与聚合肌动蛋白协调作用促进线粒体分裂。
Int J Mol Sci. 2023 Apr 1;24(7):6593. doi: 10.3390/ijms24076593.
9
The Arf family GTPases: Regulation of vesicle biogenesis and beyond.Arf 家族 GTPases：囊泡生物发生的调节及其他。
Bioessays. 2023 Jun;45(6):e2200214. doi: 10.1002/bies.202200214. Epub 2023 Mar 30.
10
ORP9 and ORP10 form a heterocomplex to transfer phosphatidylinositol 4-phosphate at ER-TGN contact sites.ORP9 和 ORP10 形成异源复合物，在 ER-TGN 接触部位转移磷脂酰肌醇 4-磷酸。
Cell Mol Life Sci. 2023 Feb 28;80(3):77. doi: 10.1007/s00018-023-04728-5.
本文引用的文献
1
Coordination of Golgi functions by phosphatidylinositol 4-kinases.通过磷酸肌醇 4-激酶协调高尔基体功能。
Trends Cell Biol. 2011 Feb;21(2):113-21. doi: 10.1016/j.tcb.2010.10.002. Epub 2010 Nov 4.
2
Role of Rab GTPases in membrane traffic and cell physiology.Rab GTPases 在膜转运和细胞生理学中的作用。
Physiol Rev. 2011 Jan;91(1):119-49. doi: 10.1152/physrev.00059.2009.
3
PI4P and Rab inputs collaborate in myosin-V-dependent transport of secretory compartments in yeast.PI4P 和 Rab 输入协同作用于肌球蛋白-V 依赖性的酵母分泌小泡运输。
Dev Cell. 2011 Jan 18;20(1):47-59. doi: 10.1016/j.devcel.2010.11.006.
4
Loss-of-function and gain-of-function mutations in FAB1A/B impair endomembrane homeostasis, conferring pleiotropic developmental abnormalities in Arabidopsis.FAB1A/B中的功能丧失和功能获得性突变会损害内膜稳态，导致拟南芥出现多效性发育异常。
Plant Physiol. 2011 Feb;155(2):797-807. doi: 10.1104/pp.110.167981. Epub 2010 Dec 20.
5
Electron tomography of RabA4b- and PI-4Kβ1-labeled trans Golgi network compartments in Arabidopsis.拟南芥 RabA4b 和 PI-4Kβ1 标记的反式高尔基体网络隔室的电子断层扫描。
Traffic. 2011 Mar;12(3):313-29. doi: 10.1111/j.1600-0854.2010.01146.x. Epub 2011 Jan 7.
6
Phosphoinositides are essential coactivators for p21-activated kinase 1.磷酸肌醇是 p21 激活激酶 1 的必需共激活因子。
Mol Cell. 2010 Nov 12;40(3):493-500. doi: 10.1016/j.molcel.2010.10.015.
7
The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7.Mon1-Ccz1 复合物是晚期内体 Rab7 同源物 Ypt7 的鸟嘌呤核苷酸交换因子。
Curr Biol. 2010 Sep 28;20(18):1654-9. doi: 10.1016/j.cub.2010.08.002.
8
Manipulation of host membrane machinery by bacterial pathogens.细菌病原体对宿主膜机制的操纵。
Curr Opin Cell Biol. 2010 Aug;22(4):547-54. doi: 10.1016/j.ceb.2010.05.006. Epub 2010 Jun 9.
9
The phosphatidylinositol 4-kinase PI4KIIIalpha is required for the recruitment of GBF1 to Golgi membranes.磷脂酰肌醇 4-激酶 PI4KIIIalpha 对于 GBF1 向高尔基体膜的募集是必需的。
J Cell Sci. 2010 Jul 1;123(Pt 13):2273-80. doi: 10.1242/jcs.055798. Epub 2010 Jun 8.
10
Phosphatidylinositol 4-phosphate controls both membrane recruitment and a regulatory switch of the Rab GEF Sec2p.磷脂酰肌醇 4-磷酸控制 Rab GEF Sec2p 的膜募集和调节开关。
Dev Cell. 2010 May 18;18(5):828-40. doi: 10.1016/j.devcel.2010.03.016.
Zotero 插件