A.I.R.C. Laboratory of Immunology and Tumors, Department of Experimental and Laboratory Medicine, G. Gaslini Institute, Genova, Italy.
Cytokine Growth Factor Rev. 2011 Jun;22(3):149-56. doi: 10.1016/j.cytogfr.2011.05.003. Epub 2011 Jul 20.
B-acute lymphoblastic leukemia (ALL) is the most common hematologic tumor of pediatric age. Although patient survival has been improved, some cases still relapse and need alternative therapies. In this context, the role of microRNA in cancer is actually matter of investigation due to their regulatory function implicated in human tumorigenesis since the main target mRNA transcripts are involved in proliferation, apoptosis and differentiation. On the other hand, cytokines are actually used as adjuvants in B-ALL therapy, and recent studies reported that they may also function by acting directly against leukemic cells. Here we review the current knowledge about the role of miRNA and cytokines in B-ALL, highlighting the link between cytokine activity and miRNA expression. The translational relevance of these issues will be also discussed.
B 型急性淋巴细胞白血病（ALL）是儿科最常见的血液系统肿瘤。尽管患者的生存率已经提高，但仍有部分病例复发，需要替代疗法。在此背景下，miRNA 在癌症中的作用实际上是一个研究的课题，因为它们的调节功能与人类肿瘤发生有关，因为主要的靶 mRNA 转录本参与增殖、凋亡和分化。另一方面，细胞因子实际上被用作 B-ALL 治疗的佐剂，最近的研究报告表明，它们也可能通过直接作用于白血病细胞来发挥作用。在这里，我们回顾了 miRNA 和细胞因子在 B-ALL 中的作用的现有知识，强调了细胞因子活性和 miRNA 表达之间的联系。这些问题的转化相关性也将进行讨论。
