Brown T C, Gregory M, Bell B, Clare D
Department of Anaesthesia, Royal Children's Hospital, Melbourne, Victoria, Australia.
Anaesth Intensive Care. 1990 Nov;18(4):460-5. doi: 10.1177/0310057X9001800407.
The rate of onset of action of d-tubocurarine (64 patients) or alcuronium (36 patients) was studied electromyographically in 100 children who had abdominal, bone or cerebral tumours. It was found that there was a significantly delayed onset (over three times longer than controls) or additional doses were required in patients with malignant liver, renal and bone tumours who received d-tubocurarine. The onset of alcuronium blockade was also prolonged but to a lesser extent. When tumours with an abnormal prolongation of onset of relaxation were successfully treated by chemotherapy and/or surgery, the response reverted to normal. Children with benign tumours or masses had normal responses. In contrast, neuroblastomas were associated with little prolongation of onset. Cerebral tumours showed a variable response, with the observed changes being unreliable indicators of degree of malignancy.
在100名患有腹部、骨骼或脑部肿瘤的儿童中，通过肌电图研究了d - 筒箭毒碱（64例患者）或阿库氯铵（36例患者）的起效速率。研究发现，接受d - 筒箭毒碱治疗的恶性肝、肾和骨肿瘤患者的起效时间显著延迟（比对照组长三倍以上），或者需要额外增加剂量。阿库氯铵阻滞的起效时间也延长，但程度较轻。当通过化疗和/或手术成功治疗了起效时间异常延长的肿瘤时，反应恢复正常。患有良性肿瘤或肿块的儿童反应正常。相比之下，神经母细胞瘤的起效时间延长很少。脑肿瘤表现出不同的反应，观察到的变化并不能可靠地反映恶性程度。
