阿库氯铵和d -筒箭毒碱在婴儿、儿童及青少年中的剂量反应。

Dose response of alcuronium and d-tubocurarine in infants, children and adolescents.

作者信息

Meretoja O A, Brown T C, Clare D

机构信息

Department of Anaesthesia, Royal Children's Hospital, Melbourne.

出版信息

Anaesth Intensive Care. 1990 Nov;18(4):449-51. doi: 10.1177/0310057X9001800404.

DOI:10.1177/0310057X9001800404

PMID:2268007

Abstract

Seventy neonatal to adolescent general surgical patients were studied to create an individual dose-response curve for the long-acting neuromuscular blocking agents, alcuronium and d-tubocurarine. The mean (SEM) ED95 of alcuronium was 196 (9), 271 (13) and 243 (8) micrograms/kg in infants, children and adolescents, respectively (P less than 0.01). d-tubocurarine showed a similar age dependent dose-response relationship. ED95 doses were 414 (40), 499 (41) and 445 (31) micrograms/kg, respectively. The onset time (time from intravenous administration to maximal effect) following equipotent dosages was 40-50% shorter in infants than in children or adolescents (1.5 vs 2.7 minutes, P less than 0.05).

摘要

对70例新生儿至青少年普通外科患者进行了研究，以建立长效神经肌肉阻滞剂阿库氯铵和d-筒箭毒碱的个体剂量反应曲线。阿库氯铵在婴儿、儿童和青少年中的平均（标准误）ED95分别为196（9）、271（13）和243（8）微克/千克（P<0.01）。d-筒箭毒碱显示出类似的年龄依赖性剂量反应关系。ED95剂量分别为414（40）、499（41）和445（31）微克/千克。等效剂量后的起效时间（从静脉给药到最大效应的时间）在婴儿中比儿童或青少年短40-50%（1.5分钟对2.7分钟，P<0.05）。