京都大学反应堆用于硼中子俘获疗法的生物医学辐照系统。

Biomedical irradiation system for boron neutron capture therapy at the Kyoto University Reactor.

作者信息

Kobayashi T, Kanda K, Ujeno Y, Ishida M R

机构信息

Kyoto University Research Reactor Institute, Osaka, Japan.

出版信息

Basic Life Sci. 1990;54:321-39. doi: 10.1007/978-1-4684-5802-2_25.

DOI:10.1007/978-1-4684-5802-2_25

PMID:2176458

Abstract

Physics studies related to radiation source, spectroscopy, beam quality, dosimetry, and biomedical applications using the Kyoto University Reactor Heavy Water Facility are described. Also, described are a Nickel Mirror Neutron Guide Tube and a Super Mirror Neutron Guide Tube that are used both for the measurement of boron concentration in phantom and living tissue and for precise measurements of neutron flux in phantom in the presence of both light and heavy water. Discussed are: (1) spectrum measurements using the time of flight technique, (2) the elimination of gamma rays and fast neutrons from a thermal neutron irradiation field, (3) neutron collimation without producing secondary gamma rays, (4) precise neutron flux measurements, dose estimation, and the measurement of boron concentration in tumor and its periphery using guide tubes, (5) the dose estimation of boron-10 for the first melanoma patient, and (6) special-purpose biological irradiation equipment. Other related subjects are also described.

摘要

描述了与使用京都大学反应堆重水设施的辐射源、光谱学、束流质量、剂量测定和生物医学应用相关的物理研究。还描述了一种镍镜中子导管和一种超镜中子导管，它们既用于测量模型和活体组织中的硼浓度，也用于在轻水和重水同时存在的情况下精确测量模型中的中子通量。讨论的内容包括：(1) 使用飞行时间技术进行光谱测量；(2) 从热中子辐照场中消除伽马射线和快中子；(3) 不产生次级伽马射线的中子准直；(4) 使用导管进行精确的中子通量测量、剂量估计以及肿瘤及其周边硼浓度的测量；(5) 对首例黑色素瘤患者进行硼 - 10的剂量估计；(6) 专用生物辐照设备。还描述了其他相关主题。