钆中子俘获疗法对兔VX-2皮下肿瘤生长的抑制作用
Suppression of rabbit VX-2 subcutaneous tumor growth by gadolinium neutron capture therapy.
作者信息
Akine Y, Tokita N, Tokuuye K, Satoh M, Churei H, Le Pechoux C, Kobayashi T, Kanda K
机构信息
Outpatient Clinic, National Cancer Center Hospital, Tokyo, Japan.
出版信息
Jpn J Cancer Res. 1993 Aug;84(8):841-3. doi: 10.1111/j.1349-7006.1993.tb02055.x.
VX-2 tumors growing in hind legs of New Zealand White rabbits (n = 4) were exposed to thermal neutrons for 40 min (2.1 x 10(12) neutrons cm-2) while one of two hind leg tumors of each rabbit was infused continuously with meglumine gadopentetate through a branch of the left femoral artery. The contralateral (uninfused) tumors served as controls. Although no differential distribution of gadolinium was achieved between the tumor and its adjacent normal tissue, the gadolinium concentration in the infused tumor was approximately 5-6 fold higher than that in the contralateral tumor. Growth of gadolinium-infused tumors was significantly inhibited compared to that of control tumors (P < 0.05) between the 16th and 23rd days after treatment.
将生长在新西兰白兔后腿的VX-2肿瘤（n = 4）暴露于热中子40分钟（2.1×10¹² 中子/cm²），同时通过左股动脉的一个分支向每只兔子的两条后腿肿瘤中的一个持续注入钆喷酸葡胺。对侧（未注入）肿瘤作为对照。虽然肿瘤与其相邻正常组织之间未实现钆的差异分布，但注入肿瘤中的钆浓度比侧肿瘤中的钆浓度高约5 - 6倍。与对照肿瘤相比，注入钆的肿瘤在治疗后第16天至第23天之间的生长受到显著抑制（P < 0.05）。
Zotero 插件