Department of Internal Medicine, National Taiwan University College of Medicine, Taipei; Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Ann Oncol. 2012 Jan;23(1):153-158. doi: 10.1093/annonc/mdr334. Epub 2011 Jul 15.
The association between diabetes and non-Hodgkin's lymphoma (NHL) is rarely studied and the risk associated with insulin use is not known.
The crude and age-standardized trends of NHL incidence in the general population from 1979 to 2007 were first calculated. NHL prevalence and annual incidence in 2005 were calculated in 329,198 insurants aged≥45 years from a random sample of 1,000,000 insurants of the National Health Insurance. The risk factors were evaluated using logistic regression.
NHL incidence trends increased significantly in either sex. A total of 1079 and 148 NHL cases were identified for prevalence and incidence analyses, respectively. The respective prevalence (per 100,000) for diabetic and nondiabetic subjects was 480.2 and 269.9 (P<0.01), and the respective incidence (per 100,000) was 70.9 and 35.3 (P<0.01). Odds ratio for diabetic versus nondiabetic subjects after adjustment for age, sex, occupation, and living region was 1.51 (95% confidence interval 1.33-1.71) for prevalence and 1.48 (1.06-2.06) for incidence. In diabetic patients, the adjusted odds ratio for insulin users versus nonusers was 1.63 (1.23-2.15) for prevalence and 2.52 (1.37-4.64) for incidence.
NHL incidence is increasing in Taiwan. Diabetes and insulin use are associated with a higher risk.
糖尿病与非霍奇金淋巴瘤（NHL）之间的关联很少被研究，而与胰岛素使用相关的风险尚不清楚。
首先计算了 1979 年至 2007 年普通人群 NHL 发病率的粗发病率和年龄标准化趋势。从 100 万被保险人的随机样本中，选择了 329198 名年龄≥45 岁的被保险人，计算了 2005 年 NHL 的患病率和年发病率。使用逻辑回归评估危险因素。
无论性别如何，NHL 发病率趋势均明显上升。在患病率和发病率分析中，分别确定了 1079 例和 148 例 NHL 病例。糖尿病和非糖尿病患者的相应患病率（每 10 万人）分别为 480.2 和 269.9（P<0.01），相应的发病率（每 10 万人）分别为 70.9 和 35.3（P<0.01）。调整年龄、性别、职业和居住地区后，糖尿病与非糖尿病患者相比，患病率的优势比为 1.51（95%置信区间为 1.33-1.71），发病率的优势比为 1.48（1.06-2.06）。在糖尿病患者中，调整后的胰岛素使用者与非使用者相比，患病率的优势比为 1.63（1.23-2.15），发病率的优势比为 2.52（1.37-4.64）。
台湾的 NHL 发病率正在上升。糖尿病和胰岛素的使用与更高的风险相关。
