Namani Sadie, Milenkovic Zvonko, Kuchar Ernest, Koci Remzie, Mehmeti Murat
Clinic of Infectious Diseases, University Clinical Center of Kosovo, Prishtinë, Kosovo.
J Child Neurol. 2012 Jan;27(1):46-50. doi: 10.1177/0883073811413280. Epub 2011 Jul 15.
Bacterial meningitis is a severe infection responsible for high mortality. This prospective study of 277 pediatric bacterial meningitis cases was done to identify factors predicting death in children <16 years of age living and treated in a limited-resources country (Kosovo). Of the 277 children enrolled, 60 patients (22%) developed neurologic complications, and 15 children died (5%). The following variables were strongly correlated with mortality: altered mental status on admission (relative risk [RR] = 29.9), presentation of the initial cerebrospinal fluid as thick pus (RR = 29.9), prehospital seizures (RR = 23.5) and their recurrence >24 hours after admission (RR = 11.5), age <1 month (RR = 19.3), the use of inotropic agents (RR = 11.5), and admission after 5 days' duration of illness (P < .001). The mortality rate in children in Kosovo is similar to those reported from developing countries, and this is most likely due to the unfavorable living conditions.
细菌性脑膜炎是一种导致高死亡率的严重感染性疾病。本前瞻性研究纳入了277例儿童细菌性脑膜炎病例，旨在确定在资源有限的国家（科索沃）生活和接受治疗的16岁以下儿童死亡的预测因素。在纳入的277名儿童中，60例患者（22%）出现神经系统并发症，15名儿童死亡（5%）。以下变量与死亡率密切相关：入院时精神状态改变（相对危险度[RR]=29.9）、初始脑脊液呈浓稠脓液（RR=29.9）、院前癫痫发作（RR=23.5）及其在入院后24小时以上复发（RR=11.5）、年龄<1个月（RR=19.3）、使用血管活性药物（RR=11.5）以及发病5天后入院（P<0.001）。科索沃儿童的死亡率与发展中国家报告的死亡率相似，这很可能是由于生活条件不利所致。
