体育锻炼后人体淋巴细胞中β2 -肾上腺素能受体上调与环磷酸腺苷生成的关系
Beta 2-adrenoceptor up-regulation in relation to cAMP production in human lymphocytes after physical exercise.
作者信息
Graafsma S J, van Tits L J, Willems P H, Hectors M P, Rodrigues de Miranda J F, De Pont J J, Thien T
机构信息
Department of Medicine, University of Nijmegen, The Netherlands.
出版信息
Br J Clin Pharmacol. 1990;30 Suppl 1(Suppl 1):142S-144S. doi: 10.1111/j.1365-2125.1990.tb05487.x.
The effect of isotonic bicycle exercise on beta 2-adrenoceptors and cAMP production in lymphocytes was studied. The origin of the newly exposed receptors was studied by measuring radioligand binding in the presence of hydrophylic or lipophylic 'cold' ligands. During exercise beta 2-adrenoceptor density increased from 1207 +/- 144 to 1776 +/- 152 sites/cell (56 +/- 14%). Isoprenaline induced an increase in cAMP synthesis, which was 68 +/- 15% higher than those values measured before the test. Forskolin did not induce a higher increase in cAMP production after exercise. The increase in receptor density seems not to be due to a transfer of internalized receptors to the membrane surface. We conclude that physical exercise induces an up-regulation of beta 2-adrenoceptors on lymphocytes and that these adrenoceptors are functional.
研究了等张自行车运动对淋巴细胞β2 -肾上腺素能受体及环磷酸腺苷（cAMP）生成的影响。通过在亲水性或亲脂性“冷”配体存在的情况下测量放射性配体结合，研究了新暴露受体的来源。运动期间，β2 -肾上腺素能受体密度从1207±144个位点/细胞增加到1776±152个位点/细胞（增加了56±14%）。异丙肾上腺素诱导cAMP合成增加，比测试前测量的值高68±15%。运动后，福斯高林并未诱导cAMP生成更高程度的增加。受体密度的增加似乎并非由于内化受体转移至膜表面。我们得出结论，体育锻炼可诱导淋巴细胞上β2 -肾上腺素能受体上调，且这些肾上腺素能受体具有功能。
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