β-肾上腺素能受体对急性运动的适应性
Beta-adrenoceptor adaptation to acute exercise.
作者信息
Butler J, Kelly J G, O'Malley K, Pidgeon F
出版信息
J Physiol. 1983 Nov;344:113-7. doi: 10.1113/jphysiol.1983.sp014927.
Abstract
The effects of strenuous exercise on lymphocyte beta-adrenoceptor density and responsiveness in nine men were biphasic. There was an initial increase in receptor density, seen immediately after exercise, with a subsequent decline to below pre-exercise values. In parallel, maximum isoprenaline-stimulated cyclic AMP production by lymphocytes was greatly increased at the end of exercise and decreased thereafter. The increases seen at the end of exercise may be of functional significance and may represent a response of the tissue to the demands placed upon it. After a time, however, a desensitization process takes over, possibly with a protective role.
摘要
剧烈运动对9名男性淋巴细胞β - 肾上腺素能受体密度和反应性的影响是双相的。运动后立即出现受体密度的初始增加，随后下降至运动前水平以下。与此同时，淋巴细胞对异丙肾上腺素刺激产生的最大环磷酸腺苷（cAMP）产量在运动结束时大幅增加，之后下降。运动结束时出现的增加可能具有功能意义，可能代表组织对其所承受需求的一种反应。然而，一段时间后，脱敏过程开始起作用，可能具有保护作用。
相似文献
1
Beta-adrenoceptor adaptation to acute exercise.β-肾上腺素能受体对急性运动的适应性
J Physiol. 1983 Nov;344:113-7. doi: 10.1113/jphysiol.1983.sp014927.
2
Beta-adrenoceptor changes in human lymphocytes, induced by dynamic exercise.动态运动诱导的人淋巴细胞β-肾上腺素能受体变化
Naunyn Schmiedebergs Arch Pharmacol. 1984 Feb;325(2):190-2. doi: 10.1007/BF00506201.
3
Acute regulation of lymphocyte beta 2-adrenoceptors is altered in patients with essential hypertension.原发性高血压患者淋巴细胞β2 - 肾上腺素能受体的急性调节发生改变。
J Hypertens Suppl. 1985 Dec;3(3):S149-52.
4
Terbutaline-induced desensitization of human lymphocyte beta 2-adrenoceptors. Accelerated restoration of beta-adrenoceptor responsiveness by prednisone and ketotifen.特布他林诱导的人淋巴细胞β2 -肾上腺素能受体脱敏。泼尼松和酮替芬加速β -肾上腺素能受体反应性的恢复。
J Clin Invest. 1985 Sep;76(3):1096-101. doi: 10.1172/JCI112063.
5
Forskolin potentiates isoproterenol induced beta adrenoceptor desensitization in intact human lymphocytes.福司可林增强异丙肾上腺素诱导的完整人淋巴细胞中的β肾上腺素能受体脱敏。
Res Commun Chem Pathol Pharmacol. 1988 Jul;61(1):3-16.
6
Comparison of changes in the characteristics of beta-adrenoceptors and responsiveness of human circulating lymphocytes during and after chronic administration of pindolol and propranolol.慢性服用吲哚洛尔和普萘洛尔期间及之后人体循环淋巴细胞β-肾上腺素能受体特征变化及反应性的比较
Eur J Clin Pharmacol. 1984;26(1):7-12. doi: 10.1007/BF00546700.
7
Impaired regulation of beta-adrenoceptors in patients on maintenance haemodialysis.维持性血液透析患者β-肾上腺素能受体调节受损。
Proc Eur Dial Transplant Assoc Eur Ren Assoc. 1985;21:178-84.
8
Reduced beta 2-adrenoceptor responsiveness in exercise-induced asthma.运动诱发性哮喘中β2肾上腺素能受体反应性降低
Chest. 1985 Oct;88(4):594-600. doi: 10.1378/chest.88.4.594.
9
Density and functioning of human lymphocytic beta-adrenergic receptors during prolonged physical exercise.长时间体育锻炼期间人类淋巴细胞β-肾上腺素能受体的密度与功能
Acta Physiol Scand. 1989 Aug;136(4):569-74. doi: 10.1111/j.1748-1716.1989.tb08703.x.
10
Alterations of beta-adrenoceptors on human leukocyte subsets induced by dynamic exercise: effect of prednisone.动态运动诱导的人白细胞亚群β-肾上腺素能受体的变化：泼尼松的作用
Clin Exp Pharmacol Physiol. 1988 Jan;15(1):43-53. doi: 10.1111/j.1440-1681.1988.tb01007.x.
引用本文的文献
1
Is the Sympathetic System Detrimental in the Setting of Septic Shock, with Antihypertensive Agents as a Counterintuitive Approach? A Clinical Proposition.在感染性休克的情况下，交感神经系统是否有害，使用抗高血压药物作为一种有悖常理的方法是否可行？一项临床提议。
J Clin Med. 2021 Oct 1;10(19):4569. doi: 10.3390/jcm10194569.
2
Hypothesis: Fever control, a niche for alpha-2 agonists in the setting of septic shock and severe acute respiratory distress syndrome?假设：在脓毒性休克和严重急性呼吸窘迫综合征的情况下，控制发热是α-2激动剂的一个应用领域？
Temperature (Austin). 2018 May 22;5(3):224-256. doi: 10.1080/23328940.2018.1453771. eCollection 2018.
3
Dexmedetomidine: Current Role in Burn ICU.右美托咪定：在烧伤重症监护病房中的当前作用
Transl Med UniSa. 2017 Jul 1;16:1-10. eCollection 2017 Jan.
4
Pressor Response to Noradrenaline in the Setting of Septic Shock: Anything New under the Sun-Dexmedetomidine, Clonidine? A Minireview.脓毒性休克时去甲肾上腺素的升压反应：阳光下可有新进展——右美托咪定、可乐定？一篇综述。
Biomed Res Int. 2015;2015:863715. doi: 10.1155/2015/863715. Epub 2015 Dec 13.
5
Effect of acute and short-term oral salbutamol treatments on maximal power output in non-asthmatic athletes.急性和短期口服沙丁胺醇治疗对非哮喘运动员最大输出功率的影响。
Eur J Appl Physiol. 2012 Sep;112(9):3251-8. doi: 10.1007/s00421-011-2307-3. Epub 2012 Jan 10.
6
Adhesion molecules, catecholamines and leucocyte redistribution during and following exercise.运动期间及运动后黏附分子、儿茶酚胺与白细胞再分布
Sports Med. 2003;33(4):261-84. doi: 10.2165/00007256-200333040-00002.
7
Effects of swimming training on aerobic capacity and exercise induced bronchoconstriction in children with bronchial asthma.游泳训练对支气管哮喘患儿有氧能力及运动诱发性支气管收缩的影响。
Thorax. 1999 Mar;54(3):196-201. doi: 10.1136/thx.54.3.196.
8
Exercise and the experience and appraisal of daily stressors: a naturalistic study.运动与日常压力源的体验及评估：一项自然主义研究。
J Behav Med. 1998 Aug;21(4):363-74. doi: 10.1023/a:1018778730309.
9
Expression of the beta 2 adrenoceptor partial agonist/antagonist activity of salbutamol in states of low and high adrenergic tone.沙丁胺醇的β2肾上腺素能受体部分激动剂/拮抗剂活性在低肾上腺素能张力和高肾上腺素能张力状态下的表现。
Thorax. 1995 Feb;50(2):134-8. doi: 10.1136/thx.50.2.134.
10
Catecholamines, lymphocyte subsets, and cyclic adenosine monophosphate production in mononuclear cells and CD4+ cells in response to submaximal resistance exercise.次最大阻力运动后，单核细胞和CD4+细胞中儿茶酚胺、淋巴细胞亚群及环磷酸腺苷的产生情况
Eur J Appl Physiol Occup Physiol. 1995;71(2-3):166-72. doi: 10.1007/BF00854975.
本文引用的文献
1
Radioenzymatic determination of epinephrine, norepinephrine and dopamine in 0.1 ml plasma samples: plasma catecholamine response to submaximal and near maximal exercise.0.1毫升血浆样本中肾上腺素、去甲肾上腺素和多巴胺的放射酶法测定：血浆儿茶酚胺对次最大和接近最大运动的反应。
J Clin Chem Clin Biochem. 1980 Jun;18(6):367-72. doi: 10.1515/cclm.1980.18.6.367.
2
Relationship of beta-adrenoreceptor density to fitness in athletes.运动员β-肾上腺素能受体密度与体能的关系
Nature. 1982 Jul 1;298(5869):60-2. doi: 10.1038/298060a0.
3
Regulation of human leukocyte beta receptors by endogenous catecholamines: relationship of leukocyte beta receptor density to the cardiac sensitivity to isoproterenol.内源性儿茶酚胺对人白细胞β受体的调节：白细胞β受体密度与心脏对异丙肾上腺素敏感性的关系。
J Clin Invest. 1981 Jun;67(6):1777-84. doi: 10.1172/jci110217.
4
Age and beta adrenoceptor-mediated function.年龄与β肾上腺素能受体介导的功能。
Clin Pharmacol Ther. 1980 Jun;27(6):769-72. doi: 10.1038/clpt.1980.108.
5
Human lymphocyte beta-adrenoceptor density in relation to age and hypertension.人类淋巴细胞β-肾上腺素能受体密度与年龄及高血压的关系。
J Cardiovasc Pharmacol. 1982 Sep-Oct;4(5):738-40. doi: 10.1097/00005344-198209000-00007.
6
Biphasic adrenergic modulation of beta-adrenergic receptors in man. Agonist-induced early increment and late decrement in beta-adrenergic receptor number.人体β-肾上腺素能受体的双相肾上腺素能调节。激动剂诱导的β-肾上腺素能受体数量的早期增加和晚期减少。
J Clin Invest. 1980 Apr;65(4):836-40. doi: 10.1172/JCI109735.
7
8
Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding.通过（-）（3H）阿普洛尔结合鉴定人淋巴细胞中的β-肾上腺素能受体。
J Clin Invest. 1976 Jan;57(1):149-55. doi: 10.1172/JCI108254.
9
Rapid changes in rat pineal beta-adrenergic receptor: alterations in l-(3H)alprenolol binding and adenylate cyclase.大鼠松果体β-肾上腺素能受体的快速变化：L-(3H)阿普洛尔结合及腺苷酸环化酶的改变
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3735-9. doi: 10.1073/pnas.72.9.3735.
10
Plasma catecholamine levels in the coronary sinus, the left renal vein and peripheral vessels in healthy males at rest and during exercise.健康男性在静息和运动状态下冠状窦、左肾静脉及外周血管中的血浆儿茶酚胺水平。
Acta Physiol Scand. 1978 Nov;104(3):364-9. doi: 10.1111/j.1748-1716.1978.tb06288.x.
Zotero 插件