Cernescu C, Constantinescu S N, Popescu L M
Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
Rev Roum Virol. 1990 Apr-Jun;41(2):93-6.
The penetration of vesicular stomatitis virus (VSV) into the target cells is known to depend on the acid triggered receptor-mediated endocytosis pathway (RME). However, the possible contribution of phagocytosis and macropinocytosis both at early and late stages of infection and of plaque-forming process is unknown. Electron microscopic images of fibroblasts obtained one hour after VSV adsorption at 37 degrees C showed RME vesicles as well as clusters of particles in cytoplasmic inlets and phagocytic vacuoles which are morphologically similar with macropinosomes. Therefore, the possibility that VSV can use, in addition to RME, phagocytosis and macropinocytosis is discussed with respect to the wide range of host cell VSV infectivity and binding as well as to pseudotype formation.
已知水泡性口炎病毒（VSV）进入靶细胞依赖于酸触发的受体介导的内吞途径（RME）。然而，在感染的早期和晚期以及噬斑形成过程中，吞噬作用和巨胞饮作用可能发挥的作用尚不清楚。在37℃下VSV吸附1小时后获得的成纤维细胞的电子显微镜图像显示，存在RME囊泡以及细胞质入口处的颗粒簇和与巨胞饮体形态相似的吞噬泡。因此，就VSV广泛的宿主细胞感染性、结合以及假型形成而言，讨论了VSV除了利用RME之外还能利用吞噬作用和巨胞饮作用的可能性。
