Department of Vitreo-Retinal Surgery, Center of Ophthalmology, University of Cologne, Cologne, Germany.
Retina. 2012 Jan;32(1):38-42. doi: 10.1097/IAE.0b013e3182173753.
To investigate preoperative aqueous flare as a predictive factor for proliferative vitreoretinopathy (PVR) redetachment in patients with rhegmatogenous retinal detachment.
Preoperatively, the aqueous flare of 116 consecutive patients with retinal detachment was measured quantitatively with a laser flare-cell meter (Kowa FM-500; Kowa Company, Ltd, Tokyo, Japan). Seventy-four healthy partner eyes and 41 eyes of healthy age-matched patients served as controls. At least 6 months after surgery, patients were reevaluated, whether surgery was performed again because of PVR redetachment.
Eyes with retinal detachment that developed PVR redetachment later on (n = 12) had higher flare values than eyes with uncomplicated retinal detachment (n = 104) (median, 27.63 vs. 8.83 photon counts per millisecond; P < 0.0001). No eye with PVR redetachment had a flare value <10.8 photon counts per millisecond. In eyes with flare values exceeding 15 photon counts per millisecond, the odds of PVR redetachment development increases 16-fold.
Our study shows that the breakdown of the blood-ocular barrier as determined by aqueous flare is a major risk factor for PVR redetachment. The laser flare-cell meter is a fast, noninvasive, and safe tool that allows predicting the PVR redetachment risk preoperatively. It provides the surgeon with an estimate to choose those patients who could benefit from intravitreal drugs to prevent PVR.
研究术前房水闪辉作为孔源性视网膜脱离患者发生增生性玻璃体视网膜病变（PVR）再脱离的预测因子。
用激光闪辉细胞仪（Kowa FM-500；日本 Kowa 公司）对 116 例连续视网膜脱离患者的房水闪辉进行定量检测。74 只健康对侧眼和 41 只年龄匹配的健康患者眼作为对照。术后至少 6 个月，对患者进行重新评估，是否因 PVR 再脱离而再次手术。
后来发生 PVR 再脱离的视网膜脱离眼（n = 12）的闪辉值高于无并发症的视网膜脱离眼（n = 104）（中位数，27.63 与 8.83 个光子/毫秒；P < 0.0001）。无 PVR 再脱离的眼闪辉值<10.8 个光子/毫秒。闪辉值超过 15 个光子/毫秒时，PVR 再脱离的发生几率增加 16 倍。
我们的研究表明，血眼屏障的破坏（通过房水闪辉确定）是 PVR 再脱离的主要危险因素。激光闪辉细胞仪是一种快速、非侵入性和安全的工具，可以预测术前 PVR 再脱离的风险。它为外科医生提供了一个估计值，可以选择那些可能受益于眼内药物预防 PVR 的患者。
