Amann T, Nguyen N X, Küchle M
Augenklinik mit Poliklinik, Universität Erlangen-Nürnberg.
Klin Monbl Augenheilkd. 1997 Jan;210(1):43-7. doi: 10.1055/s-2008-1035012.
Aim of this study was the investigation of changes of aqueous flare and cells in eyes with retinal detachment.
We examined 62 eyes of 61 patients with retinal detachment (56 eyes with rhegmatogenous retinal detachment, 6 eyes with traction retinal detachment; 51 eyes without and 11 eyes with clinical signs of proliferative vitreoretinopathy (PVR) stage C) with the laser flare-cell meter (LFCM) and compared the results with clinical findings and with the results of a control group.
The flare values as well as the cell count of all eyes with retinal detachment were significantly elevated (p < 0.0001) in comparison to those of the control group. In eyes with PVR a significant elevation of flare values in comparison to eyes without PVR appeared (p = 0.0052). A slight correlation was found between the extension of the detachment and the flare values and the cell count, respectively. In cases with rhegmatogenous retinal detachment a significant elevation of the cell count was found if the largest break was localized in the upper hemisphere (p = 0.03) or if the macula was affected (p = 0.02). In rhegmatogenous retinal detachment, the cell count correlated slightly with the age of the patients (r = 0.3, p = 0.02), and flare values correlated with the height of the detachment (r = 0.28, p = 0.04).
Our results demonstrate a breakdown of the blood-ocular barriers in eyes with retinal detachment and an elevation of corpuscular elements in aqueous as manifestations of pseudouveitis. In eyes with PVR the alteration of blood-ocular barriers seems to be more extensive than in eyes without PVR indicating a possible role of the LFCM for early detection of PVR.
本研究旨在调查视网膜脱离患者房水闪光和细胞的变化。
我们使用激光闪光细胞仪（LFCM）检查了61例视网膜脱离患者的62只眼（56只孔源性视网膜脱离眼，6只牵拉性视网膜脱离眼；51只无增殖性玻璃体视网膜病变（PVR）C期临床体征的眼和11只伴有PVR C期临床体征的眼），并将结果与临床发现以及对照组的结果进行比较。
与对照组相比，所有视网膜脱离眼的闪光值和细胞计数均显著升高（p < 0.0001）。与无PVR的眼相比，有PVR的眼闪光值显著升高（p = 0.0052）。分别发现脱离范围与闪光值和细胞计数之间存在轻微相关性。在孔源性视网膜脱离病例中，如果最大裂孔位于上半球（p = 0.03）或黄斑受累（p = 0.02），则细胞计数显著升高。在孔源性视网膜脱离中，细胞计数与患者年龄略有相关（r = 0.3，p = 0.02），闪光值与脱离高度相关（r = 0.28，p = 0.04）。
我们的结果表明，视网膜脱离眼存在血-眼屏障破坏和房水中细胞成分升高，这是假葡萄膜炎的表现。与无PVR的眼相比，有PVR的眼血-眼屏障改变似乎更广泛，这表明LFCM可能在PVR的早期检测中发挥作用。
