Cole J T
Section on Hematology and Oncology, Ochsner Clinic and Alton Ochsner Medical Foundation, New Orleans, LA.
Ochsner J. 2000 Jan;2(1):24-32.
A number of advances have been made over the last decade in the systemic therapy of breast cancer, including 1) the introduction of the taxanes, paclitaxel and docetaxel, into the treatment regimes for both early and advanced breast cancer; 2) a greater understanding of the use of high-dose chemotherapy, supplemented with stem cell rescue; 3) the development of newer parenteral and oral chemotherapeutic drugs; 4) the first biologic therapy for breast cancer; 5) the first demonstration of effective drug therapy to prevent the development of breast cancer; and 6) effective agents to palliate and/or prevent complications from bone metastasis. These and other developments are allowing both the extension of life and a better quality of life for those stricken with the breast cancer.
在过去十年中，乳腺癌的全身治疗取得了许多进展，包括：1）将紫杉烷类药物紫杉醇和多西他赛引入早期和晚期乳腺癌的治疗方案；2）对大剂量化疗并辅以干细胞救援的使用有了更深入的了解；3）开发了更新的肠胃外和口服化疗药物；4）第一种用于乳腺癌的生物疗法；5）首次证明有效的药物疗法可预防乳腺癌的发生；6）有效缓解和/或预防骨转移并发症的药物。这些以及其他进展使乳腺癌患者的生命得以延长，生活质量得以提高。
