5/6肾切除大鼠血浆心房利钠肽（ANP）与肾小球ANP受体之间的关系

Relation between plasma atrial natriuretic peptide (ANP) and glomerular ANP receptors in 5/6 nephrectomized rats.

作者信息

Jin H, Yuan Z Y, Du X H, Su G, Zhang L, Wang M X, Dong Y, Liu D X, Zou W Z, Wang S L

机构信息

Department of Nephrology, China-Japan Friendship Hospital, Beijing.

出版信息

Chin Med J (Engl). 1990 Oct;103(10):794-9.

PMID:2176581

Abstract

Chronic renal failure (CRF) was induced in male wistar rats (Group I) by 5/6 nephrectomy and the sham-operated ones served as control (Group II). The results showed that in Group I, plasma atrial natriuretic peptide (ANP) levels increased progressively as the Scr was elevated. Plasma R-A rose simultaneously compared to the normal (P less than 0.001). At the 20th week after operation, urine volume and Na decreased significantly (P less than 0.05). The number of glomerular receptors decreased markedly at the 12th week (P less than 0.05) and 20th week (P less than 0.01). Our data suggest that in 5/6 nephrectomized rats, the elevation of plasma ANP level might be partly caused by the damage of glomerular ANP receptors, and the elevated plasma ANP could not play its role in diuresis, natriuresis, blood pressure depression and R-A inhibition as a result of the damage of kidney ANP receptors.

摘要

通过5/6肾切除术诱导雄性Wistar大鼠（I组）发生慢性肾衰竭，假手术大鼠作为对照组（II组）。结果显示，I组中，随着血肌酐（Scr）升高，血浆心钠素（ANP）水平逐渐升高。与正常组相比，血浆肾素 - 血管紧张素（R - A）同时升高（P < 0.001）。术后第20周，尿量和尿钠显著减少（P < 0.05）。肾小球受体数量在第12周（P < 0.05）和第20周（P < 0.01）显著减少。我们的数据表明，在5/6肾切除大鼠中，血浆ANP水平升高可能部分是由于肾小球ANP受体受损所致，并且由于肾脏ANP受体受损，升高的血浆ANP无法在利尿、利钠、降压和抑制肾素 - 血管紧张素方面发挥作用。