Nitta K, Naruse M, Sanaka T, Tsuchiya K, Sugino N
Department of Medicine, Tokyo Women's Medical College, Japan.
Jpn J Exp Med. 1989 Oct;59(5):181-8.
In a study of the role of atrial natriuretic peptide (ANP) in sodium homeostasis in experimental renal failure, we found that a infusion of ANP at 0.25 microgram/min for 15 min produced an increase in the glomerular filtration rate (GFR) and fractional excretion of sodium (FENa) in five-sixth nephrectomized (5/6 Nx) rats. Renal vascular resistance (RVR) was lower during the base-line period and did not change after the administration of 100 ng/ml ANP to isolated perfused kidney (IPK) from adriamycin-treated rats. Furthermore, fractional excretion of ANP (FEANP) by IPK decreased in kidneys from adriamycin-treated rats as compared to that in kidneys from control rats. Finally, after 5/6 Nx, levels of plasma immunoreactive ANP (ir-ANP) gradually increased but excretion of water and sodium did not change during normal intake of sodium. The increase in levels of ir-ANP was accompanied by an increase in the rates of excretion of water and sodium was observed 2 days later but these rates returned to the base-line values after 2 weeks. These findings suggest that ANP plays an important role in the adjustment of acute changes in the volume of extracellular fluid during experimental renal failure.
在一项关于心房利钠肽（ANP）在实验性肾衰竭钠稳态中作用的研究中，我们发现，以0.25微克/分钟的速度输注ANP 15分钟，可使六分之五肾切除（5/6 Nx）大鼠的肾小球滤过率（GFR）和钠分数排泄（FENa）增加。在基线期，肾血管阻力（RVR）较低，给阿霉素处理大鼠的离体灌注肾（IPK）注射100 ng/ml ANP后，RVR没有变化。此外，与对照大鼠的肾脏相比，阿霉素处理大鼠肾脏的IPK对ANP的分数排泄（FEANP）降低。最后，在5/6 Nx后，血浆免疫反应性ANP（ir-ANP）水平逐渐升高，但在正常钠摄入期间，水和钠的排泄没有变化。ir-ANP水平的升高伴随着水和钠排泄率的增加，这在2天后观察到，但这些排泄率在2周后恢复到基线值。这些发现表明，ANP在实验性肾衰竭期间细胞外液量急性变化的调节中起重要作用。
