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本文引用的文献

1
Pregnancy termination using vaginal misoprostol in women with more than one caesarean section.剖宫产史不止一次的女性使用阴道米索前列醇终止妊娠。
J Obstet Gynaecol. 2007 Aug;27(6):597-600. doi: 10.1080/01443610701497561.
2
Intravaginal gemeprost and second-trimester pregnancy termination in the scarred uterus.阴道内给予吉美前列素与瘢痕子宫中期妊娠终止
Int J Gynaecol Obstet. 2007 Apr;97(1):35-9. doi: 10.1016/j.ijgo.2006.12.013. Epub 2007 Feb 22.
3
The use of vaginal misoprostol for second-trimester pregnancy termination in women with previous single cesarean section.米索前列醇阴道给药用于有单次剖宫产史女性的中期妊娠终止。
Contraception. 2006 Oct;74(4):324-7. doi: 10.1016/j.contraception.2006.03.023. Epub 2006 May 12.
4
Termination of pregnancy in patients with previous cesarean section.有剖宫产史患者的终止妊娠
Contraception. 2006 Mar;73(3):244-8. doi: 10.1016/j.contraception.2005.09.007. Epub 2005 Nov 2.
5
Risk factors associated with presenting for abortion in the second trimester.与妊娠中期进行流产相关的风险因素。
Obstet Gynecol. 2006 Jan;107(1):128-35. doi: 10.1097/01.AOG.0000189095.32382.d0.
6
Misoprostol for second-trimester pregnancy termination in women with a prior cesarean delivery.米索前列醇用于有剖宫产史女性的中期妊娠终止。
Obstet Gynecol. 2005 Feb;105(2):352-6. doi: 10.1097/01.AOG.0000151996.16422.88.
7
Silent uterine rupture following second trimester medical termination of pregnancy in a woman with an artificial urinary sphincter and three previous caesarean sections.一名植入人工尿道括约肌且既往有三次剖宫产史的女性,在孕中期药物流产后发生隐匿性子宫破裂。
J Obstet Gynaecol. 2002 Nov;22(6):687. doi: 10.1080/014436102762062367.
8
Misoprostol used alone for the termination of early pregnancy. A review of the evidence.
Contraception. 1999 Apr;59(4):209-17. doi: 10.1016/s0010-7824(99)00029-3.
9
Low-dose mifepristone 200 mg and vaginal misoprostol for abortion.低剂量米非司酮200毫克联合阴道用米索前列醇用于流产。
Contraception. 1999 Jan;59(1):1-6. doi: 10.1016/s0010-7824(98)00150-4.
10
Vaginal misoprostol administered at home after mifepristone (RU486) for abortion.米非司酮(RU486)后在家自行阴道给予米索前列醇用于流产。
J Fam Pract. 1997 Apr;44(4):353-60.

米索前列醇用于妊娠中期引产导致的隐匿性子宫破裂:一例报告

Silent uterine rupture with the use of misoprostol for second trimester termination of pregnancy : a case report.

作者信息

Cuellar Torriente Martin

机构信息

National District Hospital, P.O. Box 20147, Willows, Bloemfontein, Free State 9320, South Africa.

出版信息

Obstet Gynecol Int. 2011;2011:584652. doi: 10.1155/2011/584652. Epub 2011 Apr 19.

DOI:10.1155/2011/584652
PMID:21765835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3135046/
Abstract

Uterine rupture is an uncommon, but a life-threatening, complication following second trimester medical termination of pregnancy (TOP). The reported cases have been in both the scarred and unscarred uterus (Rajesh et al. 2002, Drey et al. 2006, and Dickinson). A 27-year-old with two previous deliveries, no previous caesarean section, no history of induced abortions, and no gynaecological operations. She presented with amenorrhoea, and according to her last normal menstruation, she was 10 weeks and 5 days. Ultrasound was done, and it reported 16 weeks and 5 days. She asked for TOP. According to the clinic's protocol, misoprostol 800 mcg (4 tabs) were given to be used vaginally as a loading dose and another three to be taken orally after that. In the following day when she attended the clinic for follow up, a manual vacuum aspiration (MVA). A manual vacuum aspiration was indicated as an incomplete abortion. During the procedure, a uterine rupture was found in the uterine lower segment. A laparotomy was done and a lineal uterine rupture was found and sutured. The patient had a good postoperative recovery and was discharged from hospital after four days. The clinician dealing with second trimester terminations should be aware of the possibility of having a uterine rupture, especially in patients with a uterine scar in order to make an early diagnosis.

摘要

子宫破裂是孕中期药物流产后一种罕见但危及生命的并发症。已报道的病例发生在有瘢痕子宫和无瘢痕子宫的患者中(拉杰什等人,2002年;德雷等人,2006年;以及迪金森)。一名27岁女性,既往有两次分娩史,无剖宫产史,无人工流产史,无妇科手术史。她因闭经就诊,根据其末次正常月经,停经10周零5天。行超声检查,报告显示停经16周零5天。她要求进行药物流产。根据诊所的方案,给予米索前列醇800微克(4片)经阴道作为负荷剂量使用,之后再口服三片。第二天她到诊所复诊时,因流产不全行人工负压吸引术(MVA)。术中发现子宫下段子宫破裂。行剖腹探查术,发现子宫线性破裂并进行了缝合。患者术后恢复良好,四天后出院。处理孕中期流产的临床医生应意识到子宫破裂的可能性,尤其是有子宫瘢痕的患者,以便早期诊断。