Daponte A, Nzewenga G, Dimopoulos K D, Guidozzi F
Department of Obstetrics and Gynaecology, University Hospital of Larissa, Larissa, Greece.
J Obstet Gynaecol. 2007 Aug;27(6):597-600. doi: 10.1080/01443610701497561.
We set out to evaluate the safety and efficacy of the proposed misoprostol regimen in women with previous multiple caesarean sections. This was a retrospective cohort study of 21 women with more than one caesarean section who underwent termination of pregnancy (TOP) with 400 mug of vaginal misoprostol followed by 200 mug/6 h (max 800 mug). The complete abortion rate was 12/21 (57.14%) and six (28.57%) women had an incomplete abortion. Three TOPs (14.29%) failed. In the first trimester group, only 3/9 (33.34%) aborted completely, while (9/12) 75% second trimester patients aborted completely. There were no major complications. The proposed regimen is considered safe and reasonably effective in second trimester TOPs in women with previous multiple caesarean sections. In first trimester patients, the possibility of manual vacuum aspiration (MVA) should be discussed during counselling, or a higher dose should be used as the effectiveness is low.
我们着手评估拟用的米索前列醇方案对有多次剖宫产史女性的安全性和有效性。这是一项回顾性队列研究，研究对象为21例有不止一次剖宫产史且接受终止妊娠（TOP）的女性，她们先经阴道给予400微克米索前列醇，随后每6小时给予200微克（最大剂量800微克）。完全流产率为12/21（57.14%），6例（28.57%）女性流产不全。3例终止妊娠（14.29%）失败。在孕早期组，仅3/9（33.34%）完全流产，而孕中期患者中有（9/12）75%完全流产。无重大并发症。对于有多次剖宫产史的女性，拟用方案在孕中期终止妊娠时被认为是安全且相当有效的。对于孕早期患者，在咨询过程中应讨论人工负压吸引术（MVA）的可能性，或者由于有效性较低应使用更高剂量。
