Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
Parkinsons Dis. 2011;2011:951874. doi: 10.4061/2011/951874. Epub 2011 Jun 12.
Purpose. To compare the quality of life (QoL) and emotional well-being of the offspring of parents with Parkinson's disease (PD) and multiple sclerosis (MS) and to consider results in light of current UK clinical guidelines. Methods. 143 adolescent and adult children of parents with PD and MS were postally administered the Parental Illness Impact Scale and a measure of emotional well-being. Results. Minimal differences were observed between the two groups in both QoL and emotional well-being. Levels of mild to moderate depression were substantially greater than those of the general population. Conclusions. The nonsignificant differences reported indicate a similar degree of impact across the two conditions assessed. A significant body of evidence demonstrates the considerable impact of parental MS, with the needs of children being acknowledged in current clinical guidelines. There is a need to similarly acknowledge the potential impact of parental Parkinson's in UK guidelines for PD.
目的。比较帕金森病（PD）和多发性硬化症（MS）父母的子女的生活质量（QoL）和情绪健康，并结合当前英国临床指南考虑结果。方法。143 名 PD 和 MS 父母的青少年和成年子女通过邮寄方式接受了父母疾病影响量表和情绪健康量表的评估。结果。两组在 QoL 和情绪健康方面差异极小。轻度至中度抑郁水平明显高于一般人群。结论。报告的无显著差异表明两种情况的影响程度相似。大量证据表明，父母 MS 会产生相当大的影响，当前的临床指南已经认识到儿童的需求。有必要在英国 PD 临床指南中同样承认父母帕金森病的潜在影响。
