Afaneh Cheguevara, Rich Barrie S, Aull Meredith J, Hartono Choli, Leeser David B, Kapur Sandip
Division of Transplantation, Department of Surgery, New York Presbyterian Hospital, Weill Cornell Medical College, 525 East 68th Street, P.O. Box 207, New York, NY 10021, USA.
J Transplant. 2011;2011:596801. doi: 10.1155/2011/596801. Epub 2011 Jun 4.
Introduction. Pancreas transplantation (PTx) is the only definitive intervention for type 1 diabetes. Medical advancements in diabetes care have led to an aging PTx candidate pool. We report our experience with patients ≥50 years of age undergoing PTx. Methods. We reviewed 136 consecutive PTx patients at our institution from 1996-2010; 17 were ≥50 years of age. We evaluated demographics, surgical complications, acute rejection (AR) rates, nonsurgical infections, and survival outcomes. Results. Demographic data was similar (P > .05) between groups, excluding age. The two groups had comparable major and minor surgical complication rates (P = .10 and P = .25, resp.). The older group had a lower 1-year and overall AR rate (P = .04 and P = .03, resp.). The incidence of non-surgical infections and overall patient and graft survival was similar between groups (P > .05). Conclusion. Older patients with type 1 diabetes are feasible candidates for PTx, as surgical morbidity, incidence of infections, and AR rates are low.
引言。胰腺移植（PTx）是1型糖尿病唯一的确定性干预措施。糖尿病护理方面的医学进步导致胰腺移植候选人群老龄化。我们报告了我们对年龄≥50岁的患者进行胰腺移植的经验。方法。我们回顾了1996年至2010年在我们机构连续进行的136例胰腺移植患者；其中17例年龄≥50岁。我们评估了人口统计学、手术并发症、急性排斥反应（AR）发生率、非手术感染情况以及生存结果。结果。除年龄外，两组间人口统计学数据相似（P > 0.05）。两组的主要和次要手术并发症发生率相当（分别为P = 0.10和P = 0.25）。年龄较大组的1年和总体急性排斥反应发生率较低（分别为P = 0.04和P = 0.03）。两组间非手术感染的发生率以及患者和移植物的总体生存率相似（P > 0.05）。结论。1型糖尿病老年患者是可行的胰腺移植候选者，因为手术发病率、感染发生率和急性排斥反应发生率较低。
