Viebahn Richard, Klein Harald, Kraemer Bernhard, Schenker Peter
Department of Surgery, Knappschaftskrankenhaus, Germany.
Clin Transpl. 2009:165-9.
Pancreas transplantation has become the major successful islet replacement therapy in type I diabetes mellitus over the last 40 years. Prognosis for these patients can be improved dramatically when pancreas transplantation is combined with transplantation of a kidney. For many years, recipients at our center averaged about 38 years old when they were transplanted. The average donor was 28 years old, suffered from traumatic brain death, and had a short ICU stay. In more recent years, both pancreas donors and recipients have been older. To verify this observation, the relevant database of our center was evaluated for donor and recipient age and for the influence of those ages on the overall results of pancreas transplantation. These data were compared to the corresponding data of Eurotransplant and OPTN, showing a dinstinctly older group of donors and recipients at our center due to a difference in various demographic and societal factors between Germany and other ET countries and the U.S. Calculation of pancreas graft and patient survival shows only insignificant influence of donor and recipient age. In conclusion, the demography of the German population has a strong impact on the age of donors and recipients at our transplant center: They are significantly older than are those in international registries. Despite this, the results of pancreas transplantation at our center are comparable to those in registry data.
在过去40年里，胰腺移植已成为I型糖尿病主要的成功胰岛替代疗法。当胰腺移植与肾脏移植联合进行时，这些患者的预后可得到显著改善。多年来，我们中心的受者移植时平均年龄约为38岁。平均供者年龄为28岁，因外伤性脑死亡入院，在重症监护病房（ICU）停留时间较短。近年来，胰腺供者和受者的年龄都有所增大。为证实这一观察结果，我们评估了中心相关数据库中供者和受者的年龄，以及这些年龄对胰腺移植总体结果的影响。将这些数据与欧洲移植协会（Eurotransplant）和器官共享联合网络（OPTN）的相应数据进行比较，结果显示，由于德国与其他欧洲移植协会国家及美国在各种人口统计学和社会因素方面存在差异，我们中心的供者和受者群体明显年龄更大。胰腺移植物和患者生存率的计算结果表明，供者和受者年龄的影响微乎其微。总之，德国人口的人口统计学特征对我们移植中心供者和受者的年龄有很大影响：他们的年龄明显高于国际登记处的记录。尽管如此，我们中心的胰腺移植结果与登记数据中的结果相当。
