脑可塑性与疾病：抑制的问题。
Brain plasticity and disease: a matter of inhibition.
机构信息
National Research Council (CNR), Neuroscience Institute, Via Moruzzi 1, I-56124 Pisa, Italy.
出版信息
Neural Plast. 2011;2011:286073. doi: 10.1155/2011/286073. Epub 2011 Jul 3.
Abstract
One major goal in Neuroscience is the development of strategies promoting neural plasticity in the adult central nervous system, when functional recovery from brain disease and injury is limited. New evidence has underscored a pivotal role for cortical inhibitory circuitries in regulating plasticity both during development and in adulthood. This paper summarizes recent findings showing that the inhibition-excitation balance controls adult brain plasticity and is at the core of the pathogenesis of neurodevelopmental disorders like autism, Down syndrome, and Rett syndrome.
摘要
神经科学的主要目标之一是发展策略，以促进成年中枢神经系统的神经可塑性，因为在大脑疾病和损伤后，功能恢复是有限的。新的证据强调了皮质抑制回路在调节发育和成年期可塑性方面的关键作用。本文总结了最近的发现，表明抑制-兴奋平衡控制着成年大脑的可塑性，是自闭症、唐氏综合征和雷特综合征等神经发育障碍发病机制的核心。
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