Galan S R, Kann P H, Gress T M, Michl P
Department of Gastroenterology, Endocrinology and Metabolism, Philipps University, Marburg, Germany.
Z Gastroenterol. 2011 Jul;49(7):832-5. doi: 10.1055/s-0029-1245969. Epub 2011 Jul 15.
Infections with Listeria monocytogenes can present clinically with a wide range of different organ manifestations such as gastroenteritis, meningoencephalitis or osteomyelitis, posing a serious threat, particularly to immunocompromised patients. We present the case of a 76-year-old female patient with advanced liver disease due to underlying haemochromatosis, who was admitted to the hospital with increasing abdominal pain. She was diagnosed with spontaneous bacterial peritonitis caused by infection with Listeria monocytogenes, which she had acquired after consuming contaminated cheese from a local supermarket chain. To the best of our knowledge, this is the first case to describe Listeria-induced spontaneous bacterial peritonitis in a patient with haemochromatosis. Both end-stage liver disease and hereditary haemochromatosis on their own impair the local and systemic immune response, thereby representing predisposing factors for acquiring Listeria monocytogenes infection. This case demonstrates a rare organ manifestation of Listeria monocytogenes infection, which can be life-threatening if not diagnosed and treated adequately, and underlines the need to identify possible sources of infection in order to apply measures to prevent the further spread of the contaminated food.
单核细胞增生李斯特菌感染在临床上可表现为多种不同的器官表现，如肠胃炎、脑膜脑炎或骨髓炎，尤其对免疫功能低下的患者构成严重威胁。我们报告一例76岁女性患者，因潜在的血色素沉着症导致晚期肝病，因腹痛加剧入院。她被诊断为单核细胞增生李斯特菌感染引起的自发性细菌性腹膜炎，她是在食用当地一家连锁超市受污染的奶酪后感染的。据我们所知，这是首例描述血色素沉着症患者中李斯特菌引起的自发性细菌性腹膜炎的病例。终末期肝病和遗传性血色素沉着症本身都会损害局部和全身免疫反应，从而成为感染单核细胞增生李斯特菌的易感因素。该病例显示了单核细胞增生李斯特菌感染罕见的器官表现，如果未得到充分诊断和治疗可能会危及生命，并强调需要识别可能的感染源，以便采取措施防止受污染食品的进一步传播。
