Williams Emily L, Casanova Manuel F
Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, Kentucky 40202, USA.
Bol Asoc Med P R. 2010 Oct-Dec;102(4):17-24.
Previous studies suggest the presence of a minicolumnopathy in autism. Minicolumnar abnormalities as well as certain migratory and proliferative defects, common to autism, may be rooted in the general mechanics of periventricular germinal cell division and maturation. Increased numbers of periventricular germinal cell/radial glia can be mimicked by a variety of different transgenic mouse models and environmental factors. These murine models and environmental factors illustrate how a fairly homogenous neuroanatomical phenotype can diverge at the genetic level. By first defining the lowest common denominator (i.e., the minicolumn) and then examining which pathways are vulnerable to involved genetic and environmental factors, we may gain a greater understanding of the pathophysiologic mechanisms underlying Autism Spectrum Conditions.
先前的研究表明自闭症存在微柱病变。自闭症常见的微柱异常以及某些迁移和增殖缺陷，可能源于脑室周围生发细胞分裂和成熟的一般机制。多种不同的转基因小鼠模型和环境因素可模拟脑室周围生发细胞/放射状胶质细胞数量的增加。这些小鼠模型和环境因素说明了相当同质的神经解剖学表型如何在基因水平上出现差异。通过首先确定最小公分母（即微柱），然后检查哪些途径易受相关基因和环境因素的影响，我们可能会对自闭症谱系障碍潜在的病理生理机制有更深入的了解。
