Kelemenova Silvia, Ostatnikova Daniela
Institute of Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Neuro Endocrinol Lett. 2009;30(4):429-36.
Autism is the most genetically influenced neuropsychiatric disorder with heritability of approximately 90%. Since genetic factors seem to play a crucial role in autism etiology, enormous attention is focused on genetic analyses of the disorder. Reelin, one of the autism candidates, is necessary in regulation of neuronal migration during brain development and also in maintaining synaptic plasticity during postnatal life period. Reduced reelin levels were observed in sera and brain cortices of autistic patients. In this review, abnormalities in reelin signaling and the relationship between reelin deficiency and principal neuroendocrine pathways are discussed.
自闭症是遗传影响最为显著的神经精神疾病，遗传度约为90%。由于遗传因素似乎在自闭症病因中起着关键作用，因此对该疾病的基因分析受到了极大关注。Reelin是自闭症候选基因之一，在大脑发育过程中对神经元迁移的调节以及出生后维持突触可塑性方面都很必要。在自闭症患者的血清和大脑皮层中观察到Reelin水平降低。在这篇综述中，我们讨论了Reelin信号通路的异常以及Reelin缺乏与主要神经内分泌途径之间的关系。
