Laboratory of Clinical, Epidemiological, and Health Services Research, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Aichi, Japan.
J Palliat Med. 2011 Aug;14(8):929-39. doi: 10.1089/jpm.2010.0522. Epub 2011 Jul 18.
Recently observed trends toward increasingly aggressive end-of-life care may reflect providers' concerns that hospice may hasten death.
Using the Surveillance, Epidemiology, and End Results-Medicare linked database, we identified 7879 patients aged 65 years or older who died of advanced non-small-cell lung cancer from 1991 through 1999 after surviving for at least 3 months from their cancer diagnoses. Length of hospice admission post-cancer diagnosis and indicators of aggressive end-of-life care were ascertained based on claims data. We evaluated overall survival and care near death after controlling for baseline characteristics by using propensity score (PS) and instrumental variable analyses (IVA).
Hospice patients were older, more likely to be non-Hispanic white and female, more likely to reside in urban areas with high hospice availability and higher socioeconomic status, more likely to be treated in a teaching hospital, and received less aggressive end-of-life care compared to nonhospice patients. Among hospice patients, those experiencing short-term hospice admissions within 3 days of death were more likely to be male, reside in urban areas, be treated in a teaching hospital, and receive more aggressive end-of-life care. PS analysis found that survival favored hospice patients slightly relative to nonhospice patients by 5.0 percentage points (25.7% versus 20.7%) at 1 year and 1.4 percentage points (6.9% versus 5.5%) at 2 years postdiagnosis (p < 0.001), while there was no significant difference between those with short- and longer duration hospice stays (p = 1.00). IVA confirmed these findings.
Hospice enrollment did not compromise length of survival following advanced lung cancer diagnosis.
最近观察到的临终关怀日益激进的趋势可能反映了医护人员的担忧,即临终关怀可能会加速死亡。
利用监测、流行病学和最终结果-医疗保险链接数据库,我们确定了 7879 名年龄在 65 岁或以上的患者,他们在确诊癌症后至少存活 3 个月后死于晚期非小细胞肺癌。根据索赔数据确定癌症诊断后入院的临终关怀时间和激进的临终关怀指标。我们通过使用倾向评分(PS)和工具变量分析(IVA)来控制基线特征,评估了总体生存率和接近死亡时的护理。
临终关怀患者年龄较大,更有可能是非西班牙裔白人,女性,更有可能居住在城市地区,临终关怀可用性和社会经济地位较高,更有可能在教学医院接受治疗,并且接受的临终关怀较少。在临终关怀患者中,那些在死亡前 3 天内接受短期临终关怀的患者更有可能是男性,居住在城市地区,在教学医院接受治疗,并且接受更积极的临终关怀。PS 分析发现,与非临终关怀患者相比,临终关怀患者的生存率略高 5.0 个百分点(1 年后为 25.7%,2 年后为 20.7%)(p < 0.001),而短期和长期临终关怀停留的患者之间没有显着差异(p = 1.00)。IVA 证实了这些发现。
临终关怀的参与并没有影响晚期肺癌诊断后生存时间的长短。