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[采用Re-PUVA-C方法治疗的银屑病患者外周血白细胞中超氧自由基的产生]

[Production of superoxide free radicals by peripheral blood leukocytes in patients with psoriasis treated by the Re-PUVA-C method].

作者信息

Kaszuba A, Błaszczyk J, Ruszczak Z, Kedziora J, Czarnecki M, Kozłowska M

机构信息

Katedry i Kliniki Dermatologicznej WAM w Lodzi.

出版信息

Przegl Dermatol. 1990 Sep-Oct;77(5):307-12.

PMID:2176726
Abstract

The investigations were carried out in 20 patients with severe forms of psoriasis, and in 18 healthy subjects. The generation of free superoxide radicals by polymorphonuclear leukocytes of peripheral blood was evaluated by Bellavite et al. (1983) method by use superoxide dismutase of Sigma firm. The obtained results may confirm alterations in PMNL functions in patients with psoriasis observed by many authors. It may confirm the probability of damage of membrane structures and alterations in their bactericidal functions.

摘要

对20例重度银屑病患者和18名健康受试者进行了研究。采用Bellavite等人(1983年)的方法,使用Sigma公司的超氧化物歧化酶评估外周血多形核白细胞产生游离超氧自由基的情况。所得结果可能证实了许多作者所观察到的银屑病患者中性粒细胞功能的改变。这可能证实了膜结构受损及其杀菌功能改变的可能性。

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