School of Health and Medical Sciences, Örebro University, Sweden.
Acta Paediatr. 2012 Jan;101(1):73-7. doi: 10.1111/j.1651-2227.2011.02410.x. Epub 2011 Aug 11.
To investigate whether the age of first exposure to a high-incidence country like Sweden determines the risk of T1DM in children with an origin in a low incidence region of the world.
Register study in a Swedish study population in the age 6-25 years in three categories of residents with an origin in low incidence regions of T1DM (Eastern Europe, East Asia, South Asia and Latin America); 24,252 international adoptees; 47,986 immigrants and 40,971 Swedish-born with two foreign-born parents and a comparison group of 1,770,092 children with Swedish-born parents. Retrieval of a prescription of insulin during 2006 was used as an indicator of T1DM and analysed with logistic regression.
The odds ratios (OR) for T1DM were lower than the Swedish majority population for residents with an origin in the four low incidence regions. Being Swedish-born implied a higher risk for T1DM in the four low incidence study groups compared with the internationally adopted with an OR of 1.68 (CI 1.03-2.73).
Being born in Sweden increases the risk for T1DM in children with an origin in low incidence countries. This may imply that exposures in utero or very early infancy are important risk factors for T1DM.
研究儿童首次接触高发国家（如瑞典）的年龄是否决定了来自世界低发地区的儿童患 1 型糖尿病（T1DM）的风险。
在瑞典研究人群中进行登记研究，该人群年龄在 6-25 岁之间，分为三类：来自 T1DM 低发地区（东欧、东亚、南亚和拉丁美洲）的居民；24252 名国际收养儿童；47986 名移民和 40971 名父母双方均为外国出生的瑞典出生儿童；以及 1770092 名瑞典出生父母的对照组。2006 年胰岛素处方的检索被用作 T1DM 的指标，并使用逻辑回归进行分析。
来自四个低发地区的居民的 T1DM 比值比（OR）低于瑞典多数人群。与国际收养相比，来自四个低发研究组的瑞典出生意味着 T1DM 的风险更高，OR 为 1.68（95%CI 1.03-2.73）。
在瑞典出生会增加来自低发国家的儿童患 T1DM 的风险。这可能意味着宫内或婴儿早期的暴露是 T1DM 的重要危险因素。
