Avritscher Rony, Javadi Sanaz
Section of Interventional Radiology, Department of Diagnostic Radiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Tech Vasc Interv Radiol. 2011 Sep;14(3):124-8. doi: 10.1053/j.tvir.2011.02.004.
The goal of transcatheter arterial infusion is to achieve better tumor response by delivering chemotherapy directly into the arterial bed supplying a neoplasm. The rationale behind such therapy relies on the potentially increased tumoricidal effect afforded by higher local concentrations of the infused chemotherapic agent(s) combined with longer tissue exposure times. The use of intra-arterial chemotherapy with or without transcatheter embolization before limb salvage surgery has been demonstrated to induce substantial tumor necrosis and reduce intraoperative blood loss. Recent advances in catheter technology have greatly reduced the morbidity associated with the procedure. This article will focus on the technical aspects of intra-arterial chemotherapy for the treatment of extremity osteosarcoma.
经导管动脉灌注的目标是通过将化疗药物直接输送到供应肿瘤的动脉床，以实现更好的肿瘤反应。这种治疗方法背后的基本原理是，注入的化疗药物局部浓度升高，再加上组织暴露时间延长，可能会增强杀肿瘤效果。在保肢手术前使用动脉内化疗（无论是否联合经导管栓塞）已被证明可诱导大量肿瘤坏死并减少术中失血。导管技术的最新进展已大大降低了该手术相关的发病率。本文将重点介绍用于治疗肢体骨肉瘤的动脉内化疗的技术方面。
