1H-吡咯并[2,1-C][1,4]苯并噻嗪的合成及其与苯二氮䓬受体的结合
Synthesis and benzodiazepine receptor binding of 1H-pyrrolo[2,1-C][1,4]benzothiazines.
作者信息
Trapani G, Latrofa A, Franco M, Liso G, Genchi G
机构信息
Dipartimento Farmaco-Chimico, Facoltà di Farmacia, Università degli Studi di Bari, Italy.
出版信息
Farmaco. 1990 Jun;45(6):577-88.
PMID:2176785
Abstract
The pyrrolo[2,1-c][1,4]benzothiazines 2a-n and the pyrrolo[2,1-c][1,4]thiazine 13 were prepared and tested for their ability to displace specific [3H]diazepam binding from rat brain membranes. Such compounds were found essentially devoid of binding affinity for the benzodiazepine receptor.
摘要
制备了吡咯并[2,1 - c][1,4]苯并噻嗪类化合物2a - n和吡咯并[2,1 - c][1,4]噻嗪13，并测试了它们从大鼠脑膜中取代特异性[3H]地西泮结合的能力。发现这类化合物对苯二氮䓬受体基本没有结合亲和力。
Zotero 插件