5H-吡啶并[2,1-C][1,4]苯并噻嗪的合成及苯二氮䓬受体结合
Synthesis and benzodiazepine receptor binding of 5H-pyrido[2,1-C][1,4]benzothiazines.
作者信息
Trapani G, Latrofa A, Franco M, Liso G, Genchi G
机构信息
Dipartimento Farmaco-Chimico, Facoltà di Farmacia, Università degli Studi di Bari, Italy.
出版信息
Farmaco. 1990 Jun;45(6):589-602.
PMID:2176786
Abstract
The pyrido[2,1-c][1,4]benzothiazines 1a-t and the pyrido[2,1-c][1,4]thiazines 7a,b were prepared and tested for their ability to displace specific [3H]diazepam binding from rat brain membranes. Some of the examined compounds of type 1 and 7b showed moderate binding affinity for the benzodiazepine receptor.
摘要
制备了吡啶并[2,1 - c][1,4]苯并噻嗪类化合物1a - t和吡啶并[2,1 - c][1,4]噻嗪类化合物7a,b，并测试了它们从大鼠脑膜中取代特异性[3H]地西泮结合的能力。一些1型和7b型受试化合物对苯二氮䓬受体表现出中等结合亲和力。
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