Muttagi S S, Chaturvedi P, D'Cruz A, Kane S, Chaukar D, Pai P, Singh B, Pawar P
Head and Neck Department, Tata Memorial Hospital, E. B. Marg, Parel, Mumbai - 400 012, India.
Indian J Cancer. 2011 Apr-Jun;48(2):234-9. doi: 10.4103/0019-509X.82894.
Being a tertiary referral center, we encounter the highest number of oral cancer patients in India, and there is direct involvement of the jaw bone in approximately 40% of these cases. There are no large case series from the Indian subcontinent on metastatic tumors to the jaw bones. With this retrospective analysis, we intend to estimate the incidence of this rare manifestation in the jaw bones in our patients and compare it with the available literature.
All patients with biopsy proven metastatic disease involving jaw bones having complete clinical data were included.
Nineteen out of 10,411 oral cancer patients who reported between the years 2000 and 2005 were included. Breast and thyroid malignancies (5/19 each) were commonest in the females to metastasize to the mandible, whereas in the males, there was no predominant site that resulted in jaw bone metastasis, although mandible was commonly affected. Neuroblastoma of adrenal gland metastasized to maxilla in the age group ranging from 4 months to 16 years. maxilla was the commonest jaw bone affected in this age group. in five cases, jaw bone was found to be the first site of metastasis.
There is variation in the primary site that causes metastasis to the jaw bones depending on age, sex and geographic distribution. Jaw bone metastases are rare and can be the first site of metastasis. We get approximately four cases in a year with metastatic disease manifesting in the jaw bones. Metastasis to jaw bone is associated with poor prognosis.
作为一家三级转诊中心，我们接诊的口腔癌患者数量在印度位居首位，其中约40%的病例颌骨直接受累。印度次大陆尚无关于颌骨转移性肿瘤的大型病例系列报道。通过这项回顾性分析，我们旨在估算我们的患者中这种颌骨罕见表现的发生率，并与现有文献进行比较。
纳入所有经活检证实患有累及颌骨的转移性疾病且具备完整临床数据的患者。
纳入了2000年至2005年间报告的10411例口腔癌患者中的19例。乳腺癌和甲状腺恶性肿瘤（各5/19）是女性转移至下颌骨最常见的原发肿瘤，而在男性中，尽管下颌骨常受影响，但没有导致颌骨转移的主要原发部位。肾上腺神经母细胞瘤在4个月至16岁年龄组转移至上颌骨，该年龄组上颌骨是最常受累的颌骨。在5例病例中，颌骨被发现是转移的首发部位。
导致颌骨转移的原发部位因年龄、性别和地理分布而异。颌骨转移罕见，且可能是转移的首发部位。我们每年大约有4例颌骨出现转移性疾病的病例。颌骨转移与预后不良相关。
