Murillo Judith, Bagan Jose V, Hens Elena, Diaz Jose M, Leopoldo Manuel
Service of Stomatology and Maxillofacial Surgery, University General Hospital, Avenida Tres Cruces s/n, Valencia, Spain.
J Oral Maxillofac Surg. 2013 Sep;71(9):1545-51. doi: 10.1016/j.joms.2013.03.017. Epub 2013 Jun 22.
An analysis was performed of the clinical and epidemiologic characteristics of a group of patients diagnosed with oral metastases of distant primary tumors or unknown primary malignancies.
The study series consisted of 16 patients with oral metastatic lesions seen in the Department of Stomatology and Maxillofacial Surgery, Valencia University General Hospital (Valencia, Spain) that had been diagnosed in the previous 15 years. A retrospective analysis was made of patient age and gender, clinical characteristics of metastatic lesions, location of the primary tumor, and time elapsed from diagnosis to the death of a patient.
There were 13 male and 3 female patients (mean age, 58.8 years). Ten patients had been diagnosed previously and were being treated for a primary tumor; 2 patients were diagnosed with a primary malignancy in the department; and 4 patients presented with an unidentified primary tumor (metastatic disease diagnosed from biopsy study). The predominant clinical presentation was mixed soft tissue and bone metastases followed by solely soft tissue lesions and solely bone lesions. Some patients showed no apparent oral lesions. Primary malignancies originated mainly from the lung followed by the prostate, gastrointestinal tract, thyroid gland, breast, and liver. Mean survival from diagnosis of oral metastases was 8.25 months.
Oral metastatic lesions are infrequent, can affect male and female patients equally, can manifest at any age, and may constitute the first manifestation of a still unidentified primary malignancy. According to the literature, bone metastases are more common than soft tissue metastases. Nevertheless, in the present series, there was a clear male predominance, and the oral metastases showed a predominance of mixed presentations followed by solely soft tissue lesions and solely bone metastases.
对一组被诊断为远处原发性肿瘤或原发性恶性肿瘤不明的口腔转移瘤患者的临床和流行病学特征进行分析。
研究系列包括在巴伦西亚大学总医院口腔颌面外科（西班牙巴伦西亚）在过去15年中诊断出的16例口腔转移性病变患者。对患者的年龄和性别、转移性病变的临床特征、原发性肿瘤的位置以及从诊断到患者死亡的时间进行了回顾性分析。
有13例男性和3例女性患者（平均年龄58.8岁）。10例患者先前已被诊断并正在接受原发性肿瘤治疗；2例患者在该科室被诊断为原发性恶性肿瘤；4例患者表现为原发性肿瘤不明（通过活检研究诊断为转移性疾病）。主要临床表现为软组织和骨混合转移，其次是单纯软组织病变和单纯骨病变。一些患者没有明显的口腔病变。原发性恶性肿瘤主要起源于肺，其次是前列腺、胃肠道、甲状腺、乳腺和肝脏。从口腔转移瘤诊断后的平均生存期为8.25个月。
口腔转移性病变并不常见，可同等程度地影响男性和女性患者，可在任何年龄出现，并且可能是仍未明确的原发性恶性肿瘤的首发表现。根据文献，骨转移比软组织转移更常见。然而，在本系列中，男性明显占优势，口腔转移瘤以混合表现为主，其次是单纯软组织病变和单纯骨转移。
