Prabhakar Ramachandran, Rath Goura Kishor, Haresh Kunhi Parambath, Manoharan Nalliah, Laviraj Macherla Anjaneyulu, Rajendran Molaiyan, Julka Pramod Kumar
Department of Radiation Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
J Cancer Res Ther. 2011 Apr-Jun;7(2):168-73. doi: 10.4103/0973-1482.82917.
Tumor volume plays a crucial role in the survival and local control of the patients treated with radiotherapy. The dose volume histogram also depends on the accuracy of the tumor delineation.
The main aim is to study the variation observed in the computation of the target volume with different treatment planning systems and treatment sites.
Sixty patients of different treatment sites which include brain, retinoblastoma, head and neck, lung, gall bladder, liver, anal canal etc, were selected for this study. The tumor volume was delineated on the Eclipse treatment planning systems and CT datasets and DICOM-RT structure sets were transferred to Pinnacle, Oncentra, Plato, Precise, Ergo++, and Tomocon contouring workstations. The recomputed volume from these planning systems was compared with the reference volume obtained from Eclipse. Similarly, the accuracy in generating PTV from CTV was also assessed with different planning systems for 5 and 10 mm.
SPSS 10.0 was used for analysis.
The overall comparison of the volume with different planning systems showed that Pinnacle calculated relatively larger volume followed by Plato as compared to Eclipse, whereas TOMOCON, Ergo ++, and Oncentra showed reduced volume. As far as the variation in CTV to PTV volume is concerned, pinnacle showed a relatively higher volume as compared to the Eclipse planning systems.
The study shows that all the treatment planning systems showed variation in computing the tumor volume and the CTV to PTV generation also varied with the planning systems.
肿瘤体积在接受放射治疗患者的生存及局部控制方面起着关键作用。剂量体积直方图也取决于肿瘤轮廓勾画的准确性。
主要目的是研究不同治疗计划系统和治疗部位在靶体积计算中观察到的变化。
本研究选取了60例不同治疗部位的患者，包括脑、视网膜母细胞瘤、头颈部、肺、胆囊、肝脏、肛管等。在Eclipse治疗计划系统上勾画肿瘤体积，并将CT数据集和DICOM-RT结构集传输到Pinnacle、Oncentra、Plato、Precise、Ergo++和Tomocon轮廓勾画工作站。将这些计划系统重新计算的体积与从Eclipse获得的参考体积进行比较。同样，还使用不同的计划系统评估了5毫米和10毫米时从临床靶体积（CTV）生成计划靶体积（PTV）的准确性。
使用SPSS 10.0进行分析。
不同计划系统体积的总体比较显示，与Eclipse相比，Pinnacle计算的体积相对较大，其次是Plato，而Tomocon、Ergo++和Oncentra计算的体积较小。就CTV到PTV体积的变化而言，与Eclipse计划系统相比，Pinnacle显示出相对较大的体积。
该研究表明，所有治疗计划系统在计算肿瘤体积时均显示出差异，并且CTV到PTV的生成也因计划系统而异。
