Bratengeier Klaus, Herzog Barbara, Wegener Sonja, Holubyev Kostyantyn
Department of Radiation Oncology, University of Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany.
Martin-Luther-Universität Halle-Wittenberg, Institute of Physics, Von-Danckelmann-Platz 3, 06120, Halle (Saale), Germany.
Radiat Oncol. 2017 May 25;12(1):88. doi: 10.1186/s13014-017-0826-8.
Investigation of a reduced source to target distance to improve organ at risk sparing during stereotactic irradiation (STX).
The authors present a planning study with perfectly target-volume adapted collimator compared with multi-leaf collimator (MLC) at reduced source to virtual isocentre distance (SVID) in contrast to normal source to isocentre distance (SID) for stereotactic applications. The role of MLC leaf width and 20-80% penumbra was examined concerning the healthy tissue sparing. Several prescription schemes and target diameters are considered.
Paddick's gradient index (GI) as well as comparison of the mean doses to spherical shells at several distances to the target is evaluated. Both emphasize the same results: the healthy tissue sparing in the high dose area around the planning target volume (PTV) is improved at reduced SVID ≤ 70 cm. The effect can be attributed more to steeper penumbra than to finer leaf resolution. Comparing circular collimators at different SVID just as MLC-shaped collimators, always the GI was reduced. Even MLC-shaped collimator at SVID 70 cm had better healthy tissue sparing than an optimal shaped circular collimator at SID 100 cm. Regarding penumbra changes due to varying SVID, the results of the planning study are underlined by film dosimetry measurements with Agility™ MLC.
Penumbra requires more attention in comparing studies, especially studies using different planning systems. Reduced SVID probably allows usage of conventional MLC for STX-like irradiations.
研究缩短源到靶距离以在立体定向放射治疗(STX)期间更好地保护危及器官。
作者进行了一项计划研究,将与多叶准直器(MLC)相比能完美适配靶区体积的准直器用于立体定向应用,此时源到虚拟等中心距离(SVID)缩短,而不是常规的源到等中心距离(SID)。研究了MLC叶片宽度和20 - 80%半值层在保护健康组织方面的作用。考虑了几种处方方案和靶直径。
评估了帕迪克梯度指数(GI)以及在距靶不同距离处对球壳的平均剂量比较。两者都得出相同结果:在SVID≤70 cm时,计划靶区(PTV)周围高剂量区域的健康组织保护得到改善。这种效果更多归因于更陡峭的半值层,而非更精细的叶片分辨率。将不同SVID下的圆形准直器与MLC形状的准直器进行比较,GI总是降低的。即使是SVID为70 cm的MLC形状准直器,其对健康组织的保护也优于SID为100 cm的最佳形状圆形准直器。关于因SVID变化导致的半值层变化,计划研究的结果得到了使用Agility™ MLC进行的胶片剂量测量的证实。
在比较研究中,尤其是使用不同计划系统的研究中,半值层需要更多关注。缩短SVID可能允许在类似STX的照射中使用传统MLC。