Division of Infectious Diseases, Department of Internal Medicine, St John Hospital and Medical Center, Detroit, MI, USA.
Am J Ther. 2013 Jan;20(1):118-20. doi: 10.1097/MJT.0b013e3182204ffe.
Chemotherapeutic agents have been associated with sepsis and a variety of opportunistic and nonopportunistic infections. This was attributed to their immunosuppressive effects. Like all other chemotherapeutic agents, the use of gemcitabine has been associated with different infectious processes, yet many conditions that mimic infections have also been linked to its use. Pseudosepsis is a condition that should be added to these previously described conditions, such as gemcitabine-induced pseudocellulitis. We describe a patient who suffered from 2 different gemcitabine-induced adverse events including pseudocellulitis that was not related to prior lymphedema or radiation recall phenomenon and pseudosepsis wherein antibiotics have no role in the treatment, and the discontinuation of the offending agent resulted in the resolution of the patient's symptoms.
化疗药物与脓毒症和各种机会性及非机会性感染有关。这归因于它们的免疫抑制作用。与所有其他化疗药物一样，吉西他滨的使用也与不同的感染过程有关，但许多类似感染的情况也与它的使用有关。假性脓毒症是一种应该添加到这些先前描述的病症中的病症，例如吉西他滨诱导的假性蜂窝织炎。我们描述了一位患者，他遭受了 2 种不同的吉西他滨诱导的不良事件，包括与先前的淋巴水肿或放射回忆现象无关的假性蜂窝织炎和假性脓毒症，抗生素在治疗中没有作用，停用致病药物可导致患者症状缓解。
