Department of Internal Medicine, St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA.
Am J Ther. 2012 Jul;19(4):e141-2. doi: 10.1097/01.mjt.0000522273.81146.49.
The term "Pseudocellulitis" can be used to describe an uncomplicated nonnecrotizing inflammation of the dermis and hypodermis from a noninfectious etiology. Chemotherapeutic agents have been associated with a variety of cutaneous reactions, including radiation recall dermatitis, hypersensitivity reactions, and erysipeloid reactions. Gemcitabine (2,2-difluorodeoxycytidine) is currently being used for treatment of a variety of solid malignancies, including carcinoma of the lung. The dermatitis involved with gemcitabine is typically a radiation recall reaction whereby an inflammatory reaction occurs in the area previously treated with radiotherapy. We describe here a case of Gemcitabine-induced pseudocellulitis that was unrelated to radiation exposure and manifested in an area of lymphedema. The pseudocellulitis in such cases could be related to the drug's pharmacokinetics and may last until the drug is displaced from the subcutaneous tissue of the affected area. Antibiotics have no role in the treatment, and diphenhydramine with nonsteroidal anti-inflammatories may be used for symptomatic management.
“假性蜂窝织炎”一词可用于描述无传染性病因引起的真皮和皮下组织的单纯非坏死性炎症。化疗药物与多种皮肤反应有关，包括放射性回忆性皮炎、过敏反应和类丹毒样反应。吉西他滨（2,2-二氟脱氧胞苷）目前正被用于治疗多种实体恶性肿瘤，包括肺癌。吉西他滨引起的皮炎通常是放射性回忆反应，即在先前接受过放射治疗的区域发生炎症反应。我们在此描述了一例与放疗无关且发生于淋巴水肿区域的吉西他滨诱导的假性蜂窝织炎。在这种情况下，假性蜂窝织炎可能与药物的药代动力学有关，并且可能会持续到药物从受影响区域的皮下组织中排出。抗生素在治疗中没有作用，可使用苯海拉明和非甾体抗炎药进行对症治疗。
