From the Departments of Psychiatry and Neuroscience, McKnight Brain Institute; The University of Florida, Gainesville, FL.
J Addict Med. 2009 Mar;3(1):19-25. doi: 10.1097/ADM.0b013e31819a6e5f.
Obesity research has recognized that there are many factors contributing to this devastating disorder. Much debate has arisen among scientists to develop models that might be useful in understanding why obesity has become a major health problem and epidemic. However, much of the current debate has been fractious and causes of obesity have been attributed solely to behavior or fast food, personality issues, depression, addiction, or genetics. One of the neurohormonal and genetic causes has been found in Prader-Willi syndrome (PWS), which results in excessive, pathologic reinforcement of food. We have studied PWS to delineate the neurobiology so that environmental cue stimulation may be explained for PWS. Neuroimaging studies have shown that appetizing food and food cues are associated with appetite stimulation. Appetite control is poor in PWS, thus food cues play a major role in its regulation. Hence, PWS may be the genetic model of choice for obesity.
肥胖研究已经认识到，有许多因素导致这种破坏性的疾病。科学家们在开发可能有助于理解肥胖为何成为主要健康问题和流行病的模型方面产生了很多争议。然而，目前的许多争论都是激烈的，肥胖的原因仅仅被归因于行为或快餐、个性问题、抑郁、成瘾或遗传。其中一个神经激素和遗传原因存在于普拉德-威利综合征（PWS）中，这会导致食物过度、病理性强化。我们研究了 PWS，以阐明神经生物学，以便可以解释 PWS 的环境线索刺激。神经影像学研究表明，美味的食物和食物线索与食欲刺激有关。PWS 的食欲控制不佳，因此食物线索在其调节中起着重要作用。因此，PWS 可能是肥胖的首选遗传模型。
