Krupinski K, Basic-Micic M, Lindhoff E, Breddin H K
Department of Hematology, Medical School, Bialystok, Poland.
Blut. 1990 Nov;61(5):289-94. doi: 10.1007/BF01732879.
In 7 healthy volunteers, the effect of a single i.v. injection of 52 mg (7,500 IU) of an unfractionated heparin (UFH) and of 52.5 mg (5,000 anti XaU) of a low molecular weight heparin (LMWH) on coagulation parameters and platelet function has been studied. Thrombin-induced platelet aggregation was inhibited after the injection of both heparins. There was no significant change of ADP or collagen-induced aggregation after LMWH of UFH. Platelet adhesion to bovine extracellular matrix was not inhibited by UFH but was significantly reduced after addition in vitro and ex vivo after administration of LMWH. Further investigation should establish the time course of LMWH effects on platelet adhesion. A long duration of this effect could be partially correlated with the antithrombotic effects of LMWH.
在7名健康志愿者中，研究了单次静脉注射52毫克（7500国际单位）普通肝素（UFH）和52.5毫克（5000抗Xa单位）低分子肝素（LMWH）对凝血参数和血小板功能的影响。注射两种肝素后，凝血酶诱导的血小板聚集均受到抑制。注射LMWH或UFH后，ADP或胶原诱导的聚集无显著变化。UFH不抑制血小板与牛细胞外基质的黏附，但在体外添加以及LMWH给药后体内外添加后，血小板与牛细胞外基质的黏附显著降低。进一步的研究应确定LMWH对血小板黏附作用的时间进程。这种作用的长时间持续可能与LMWH的抗血栓作用部分相关。
