普通肝素与低分子肝素类似物对血小板功能影响的比较。
Comparison of the effect of a conventional heparin and a low molecular weight heparinoid on platelet function.
作者信息
Mikhailidis D P, Barradas M A, Mikhailidis A M, Magnani H, Dandona P
出版信息
Br J Clin Pharmacol. 1984 Jan;17(1):43-8. doi: 10.1111/j.1365-2125.1984.tb04997.x.
Abstract
In a study comparing the in vitro effects of heparin and a low molecular weight heparinoid (Organon 10172) on aggregation of platelets from normal subjects, we have demonstrated that whereas heparin markedly enhances platelet aggregation induced by other aggregators and inhibits the anti-aggregatory effect of epoprostenol (prostacyclin, PGI2), heparinoid does not produce such effects. The use of heparinoid may thus have a significant advantage over that of heparin in situations where enhanced platelet aggregation is the main factor leading to thrombosis or where heparin treatment is followed by thrombocytopaenia.
摘要
在一项比较肝素和低分子量类肝素（Organon 10172）对正常受试者血小板聚集的体外作用的研究中，我们已经证明，肝素可显著增强其他聚集剂诱导的血小板聚集，并抑制依前列醇（前列环素，PGI2）的抗聚集作用，而类肝素则不会产生此类作用。因此，在血小板聚集增强是导致血栓形成的主要因素的情况下，或在肝素治疗后出现血小板减少症的情况下，使用类肝素可能比使用肝素具有显著优势。
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