Tursi A, Elisei W, Giorgetti G, Aiello F, Brandimarte G
Gastroenterology Service, Andria, Barletta-Andria-Trani, Italy.
Minerva Gastroenterol Dietol. 2011 Sep;57(3):247-55.
Information about fecal calprotectin (FC) in segmental colitis associated with diverticulosis (SCAD) is lacking. We assessed FC in SCAD, comparing it healthy controls (HC), irritable bowel syndrome (IBS), diverticular disease (DD), ulcerative colitis (UC). Moreover, we compared FC levels in different degrees of SCAD and assessed FC SCAD before and after treatment.
Twenty-seven consecutive patients with a new endoscopic diagnosis of SCAD, and 16 patients for each control group, underwent to FC assessment. FC was assessed by semi-quantitative method.
FC was not increased in HC and in IBS patients, whilst it was increased in DD, SCAD, and UC. FC concentration was higher in SCAD and UC than in DD (SCAD vs. DD, P=0.05). No difference was found in FC concentration between SCAD and UC (P=0.213), as well as between different degree of SCAD (P= 0.178). After treatment, FC values decreased to normal values in all patients obtaining remission (P<0.0005). Three patients experienced still symptoms (one SCAD type B and two SCAD type D patients), and in all of them FC was still detectable.
FC may be useful in differentiating SCAD from functional syndromes. Moreover, it may be useful in assessing response to therapy.
关于憩室病相关性节段性结肠炎（SCAD）中粪便钙卫蛋白（FC）的信息尚缺乏。我们评估了SCAD中的FC，并将其与健康对照（HC）、肠易激综合征（IBS）、憩室病（DD）、溃疡性结肠炎（UC）进行比较。此外，我们比较了不同程度SCAD中的FC水平，并评估了治疗前后SCAD中的FC。
27例新确诊的内镜诊断为SCAD的连续患者以及每个对照组的16例患者接受了FC评估。FC采用半定量方法进行评估。
HC和IBS患者的FC未升高，而DD、SCAD和UC患者的FC升高。SCAD和UC中的FC浓度高于DD（SCAD与DD比较，P = 0.05）。SCAD和UC之间的FC浓度以及不同程度的SCAD之间均未发现差异（P = 0.178）。治疗后，所有获得缓解的患者的FC值均降至正常水平（P < 0.0005）。3例患者仍有症状（1例B型SCAD患者和2例D型SCAD患者），且所有这些患者的FC仍可检测到。
FC可能有助于将SCAD与功能性综合征区分开来。此外，它可能有助于评估治疗反应。
