Turkmen K, Gorgulu N, Uysal M, Ozkok A, Sakaci T, Unsal A, Yildiz A
Department of Nephrology, Selcuk University Meram School of Medicine, Konya, Turkey.
Indian J Nephrol. 2011 Apr;21(2):90-4. doi: 10.4103/0971-4065.82128.
Hemodialysis patients have extremely increased cardiovascular mortality. Vascular calcification, inflammation, and low serum fetuin-A levels are implicated for increased mortality. In this study, relationship between coronary artery calcification, inflammation, and serum fetuin-A levels were investigated. Seventy-eight hemodialysis patients (38 male, 40 female, mean age: 52±14.5 years) were included. All patients were on dialysis for more than 6 months. Coronary artery calcium scores (CACS) are determined by electron-beam computed tomography. Serum CRP, IL-1β, IL-6, TNF-α, and serum fetuin-A levels were measured. Mean CACS value was 488.5±94.5. Serum fetuin-A levels were negatively correlated with CACS (r:-0.30, P=0.009). Patients are divided into two groups according to total CACS value; group 1 (CACS<10), group 2 (CACS≥10). There was a statistically significance difference in fetuin-A levels between CACS group 1 and group 2 (P=0.001). In this study, serum fetuin-A levels were associated with total CACS. This Fetuin-A may play a role in increased mortality in this group of patients via facilitating CAC.
血液透析患者的心血管死亡率极高。血管钙化、炎症以及血清胎球蛋白-A水平降低与死亡率增加有关。在本研究中，对冠状动脉钙化、炎症与血清胎球蛋白-A水平之间的关系进行了调查。纳入了78例血液透析患者（男性38例，女性40例，平均年龄：52±14.5岁）。所有患者均接受透析超过6个月。通过电子束计算机断层扫描确定冠状动脉钙化评分（CACS）。测量血清CRP、IL-1β、IL-6、TNF-α以及血清胎球蛋白-A水平。平均CACS值为488.5±94.5。血清胎球蛋白-A水平与CACS呈负相关（r：-0.30，P = 0.009）。根据总CACS值将患者分为两组；第1组（CACS<10），第2组（CACS≥10）。CACS第1组和第2组之间的胎球蛋白-A水平存在统计学显著差异（P = 0.001）。在本研究中，血清胎球蛋白-A水平与总CACS相关。这种胎球蛋白-A可能通过促进冠状动脉钙化在该组患者死亡率增加中起作用。
