Powell D, McPartlin J, Skrabanek P
Eur J Clin Invest. 1978 Dec;8(6):425-6. doi: 10.1111/j.1365-2362.1978.tb00876.x.
In a patient with hypercalcaemia secondary to a renal-cell carcinoma, a concentration gradient of bioactivity was detected between the tumour effluent vein and the peripheral venous blood that was capable of stimulating adenylate cyclase in bone cells. Immuno-reactive PTH was undetectable in the tumour effluent and in the peripheral blood. It is concluded that a non-parathyroid humoral factor whose action involved cyclic AMP stimulation was responsible for the hypercalcaemia.
在一名继发于肾细胞癌的高钙血症患者中，在肿瘤流出静脉和外周静脉血之间检测到生物活性浓度梯度，该梯度能够刺激骨细胞中的腺苷酸环化酶。在肿瘤流出液和外周血中未检测到免疫反应性甲状旁腺激素（PTH）。结论是，一种作用涉及环磷酸腺苷（cAMP）刺激的非甲状旁腺体液因子是导致高钙血症的原因。
