肾细胞癌中的碱性异铁蛋白与高钙血症
Basic isoferritin and hypercalcaemia in renal cell carcinoma.
作者信息
Mufti G J, Hamblin T J, Stevens J
出版信息
J Clin Pathol. 1982 Sep;35(9):1008-10. doi: 10.1136/jcp.35.9.1008.
Abstract
A 63-year-old man with iron loss anaemia and hypercalcaemia was found to have a renal cell carcinoma. Despite the iron-deficient blood and bone marrow picture, the serum ferritin concentration was markedly raised. This was mainly due to a "basic isoferritin". The serum parathormone concentration was normal. The serum ferritin and calcium concentrations returned to normal after the tumour was removed. We propose that the renal cell carcinoma cells in this patient secreted the basic isoferritin as well as humoral factor(s) responsible for hypercalcaemia.
摘要
一名63岁男性，患有缺铁性贫血和高钙血症，被发现患有肾细胞癌。尽管存在缺铁性血液和骨髓表现，但血清铁蛋白浓度显著升高。这主要归因于一种“碱性异铁蛋白”。血清甲状旁腺激素浓度正常。肿瘤切除后，血清铁蛋白和钙浓度恢复正常。我们推测该患者的肾癌细胞分泌了碱性异铁蛋白以及导致高钙血症的体液因子。
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