Zheng Z
Zhongshan Medical College, Guangzhou.
Zhonghua Zhong Liu Za Zhi. 1990 Jul;12(4):251-3.
Eight lectins were used to study 100 cases of breast carcinoma and 56 cases of non-cancerous breast tissues by lectin histochemical method. The results showed that Bandeiraea Simplicifolia (BSL) and Peanut agglutinin (PNA) had higher positive rates in breast carcinoma than both normal breast and benign breast lesions (P less than 0.005). The positive deposit in malignant lesions was mainly located in cytoplasm while in non-malignant lesions, it was almost always lined along the lumen of glands (P less than 0.005). The authors think that expression of PNA-receptor in the cytoplasm might be associated with the mechanism that the tumor could escape from immune attack. Comparative analysis on the normal breast indicated that PNA affinity histochemistry would be useful to the understanding of the metabolism of N-acetyl-D-galactosamine during the development of normal breast and histological origin of breast carcinoma.
采用凝集素组织化学方法，用8种凝集素对100例乳腺癌及56例乳腺非癌组织进行研究。结果显示，与正常乳腺组织及乳腺良性病变相比，乳腺癌组织中，单叶豆凝集素（BSL）和花生凝集素（PNA）的阳性率较高（P<0.005）。恶性病变中的阳性沉积物主要位于细胞质中，而非恶性病变中，阳性沉积物几乎总是沿腺腔排列（P<0.005）。作者认为，细胞质中PNA受体的表达可能与肿瘤逃避免疫攻击的机制有关。对正常乳腺组织的对比分析表明，PNA亲和组织化学有助于了解正常乳腺发育过程中N-乙酰-D-半乳糖胺的代谢及乳腺癌的组织学起源。
