Lutsik A D, Birov V V, Dmitruk I M
Arkh Patol. 1986;48(7):9-14.
Distribution of lectin receptors of peanut, soy-bean, wheat ovary and concanavalin A was studied in normal and tumor human breast tissue. It is established, that in dysplasia and benign neoplasms there is a shift of lectin receptors from the apical or basal pole of acinar epithelium and ducts to the whole plasmolemma surface. There appears a mild affinity of the cytoplasm to the lectins. In carcinoma homogeneous staining of tumour cell cytoplasm and plasmolemma increase. The number of lectin receptors in the cells from low differentiated tumours decreases, a major part of the cells losing the ability of binding to lectins. Malignancy is associated with an increase in mosaic staining. The earliest signs of malignancy can be revealed with the peanut lectin.
研究了花生凝集素、大豆凝集素、小麦胚凝集素和伴刀豆球蛋白A在人正常乳腺组织和肿瘤乳腺组织中的受体分布。已证实，在发育异常和良性肿瘤中，腺泡上皮和导管的凝集素受体从顶端或基底极转移至整个质膜表面。细胞质与凝集素出现轻度亲和力。在癌组织中，肿瘤细胞质和质膜的均匀染色增加。低分化肿瘤细胞中的凝集素受体数量减少，大部分细胞失去与凝集素结合的能力。恶性肿瘤与镶嵌染色增加有关。恶性肿瘤的最早迹象可用花生凝集素检测出来。
